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We retrieved dried blood spot specimens, isolated and amplified DNA, and assayed the cancer susceptibility genes GSTT1 and GSTM1. The double null genotype was over\u2010represented in the cases, consistent with previous reports based on other epidemiological methods. The design avoids issues of participation bias by cases and controls and can be used to investigate interactions of susceptibility genes and xenobiotics in semi\u2010ecological studies. It can be useful for generating or testing hypotheses on associations of other paediatric illness and environmental contaminants.<\/jats:p>","DOI":"10.1111\/j.1365-3016.2006.00749.x","type":"journal-article","created":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T15:53:26Z","timestamp":1155570806000},"page":"449-452","source":"Crossref","is-referenced-by-count":12,"title":["Population\u2010based retrieval of newborn dried blood spots for researching paediatric cancer susceptibility genes"],"prefix":"10.1111","volume":"20","author":[{"given":"Judith","family":"Klotz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homer B.","family":"Wilcox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Dillon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerald","family":"Fagliano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,14]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"733","article-title":"Molecular epidemiology of the human glutathione S\u2010transferase genotypes GSTM1 and GSTT1 in cancer susceptibility","volume":"6","author":"Rebbeck TR","year":"1997","journal-title":"Cancer Epidemiology, Biomarkers and Prevention"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(98)00304-X"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190009059264"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199604000-00005"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3801"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-12-3817"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970303)69:1<85::AID-AJMG16>3.0.CO;2-K"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000112214.33432.cc"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/bmme.1997.2603"},{"key":"e_1_2_5_11_2","first-page":"389","article-title":"Newborn screening: a blueprint for the future","volume":"106","author":"American Academy of Pediatrics. 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