{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:34:30Z","timestamp":1791174870787,"version":"4.1.0"},"reference-count":126,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:00:00Z","timestamp":1340841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The water\u2010soluble vitamins B6, B12 and C play important roles in maternal health as well as fetal development and physiology during gestation. This systematic review evaluates the risks and benefits of interventions with vitamins B6, B12 and C during pregnancy on maternal, neonatal and child health and nutrition outcomes. Relevant publications were identified by searching PubMed, Popline and Web of Science databases. Meta\u2010analyses were conducted for outcomes where results from at least three controlled trials were available. Potential benefits of vitamin B6 supplementation were reduction in nausea and vomiting, improvement in dental health, and treatment of some cases of anaemia. In meta\u2010analysis based on three small studies, vitamin B6 supplementation had a significant positive effect on birthweight (d\u2003=\u2003217\u2003g [95% confidence interval (CI) 130, 304]). Interventions with vitamin C alone or combined with vitamin E did not systematically reduce the incidence of pre\u2010eclampsia, premature rupture of membranes, or other adverse pregnancy outcomes. In meta\u2010analyses, vitamins C and E increased the risk of pregnancy\u2010related hypertension (relative risk 1.10 [95% CI 1.02, 1.19]). Effects of vitamin B6 or C intervention on other neonatal outcomes, including preterm birth, low birthweight, and perinatal morbidity and mortality, were not significant. Data on child health outcomes were lacking. Despite the prevalence of vitamin B12 deficiency amongst populations with limited intake of animal source foods, no intervention trials have evaluated vitamin B12 supplementation before or during pregnancy. In conclusion, existing evidence does not justify vitamin C supplementation during pregnancy. Additional studies are needed to confirm positive effects of vitamin B6 supplementation on infant birthweight and other outcomes. While vitamin B12 supplementation may reduce the incidence of neural tube defects in the offspring based on theoretical considerations, research is needed to support this hypothesis.<\/jats:p>","DOI":"10.1111\/j.1365-3016.2012.01277.x","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T16:30:06Z","timestamp":1340901006000},"page":"55-74","source":"Crossref","is-referenced-by-count":90,"title":["Interventions with Vitamins B6, B12 and C in Pregnancy"],"prefix":"10.1111","volume":"26","author":[{"given":"Daphna K.","family":"Dror","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay H.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,28]]},"reference":[{"key":"e_1_2_10_2_2","volume-title":"Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline","author":"Food and Nutrition Board, Institute of Medicine","year":"1998"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/14767051003678234"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)33952-7"},{"key":"e_1_2_10_5_2","first-page":"137","volume-title":"Vitamin B6 Metabolism and Role in Growth","author":"Shane B","year":"1980"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.51.239"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/51.5.826"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.169.3952.1329"},{"key":"e_1_2_10_9_2","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1093\/jn\/106.5.680","article-title":"Influence of different levels of dietary pyridoxine on certain parameters of developing and mature brains in rats","volume":"106","author":"Aycock JE","year":"1976","journal-title":"Journal of Nutrition"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/plac.1999.0417"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016350260248210"},{"key":"e_1_2_10_12_2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/ajcn\/4.4.378","article-title":"The metabolism of vitamin B6 in human beings","volume":"4","author":"Vilter RW","year":"1956","journal-title":"American Journal of Clinical Nutrition"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2009.125"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm078"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.5.1446"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2002.10719191"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.11.2703"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2003.11.007"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1982.tb09428.x"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92170-1"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(94)E0028-7"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420320205"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02026385"},{"key":"e_1_2_10_24_2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/jn\/86.4.343","article-title":"Effect of high intakes of thiamine, riboflavin and pyridoxine on reproduction in rats and vitamin requirements of the offspring","volume":"86","author":"Schumacher MF","year":"1965","journal-title":"Journal of Nutrition"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/01443610600955826"},{"issue":"9","key":"e_1_2_10_26_2","first-page":"CD007575","article-title":"Interventions for nausea and vomiting in early pregnancy","author":"Matthews A","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.10034"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/00912700122010735"},{"key":"e_1_2_10_29_2","first-page":"336","article-title":"An antilactogenic effect of pyridoxine","volume":"88","author":"Gupta T","year":"1990","journal-title":"Journal of the Indian Medical Association"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1976.tb00848.x"},{"key":"e_1_2_10_31_2","first-page":"293","article-title":"Failure of pyridoxine to suppress raised serum prolactin levels","volume":"53","author":"de Waal JM","year":"1978","journal-title":"South African Medical Journal"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1980.tb07087.x"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1983.tb09765.x"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2003.1.62"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365527109180702"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.26947A"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2008.00031.x"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830480409"},{"key":"e_1_2_10_39_2","first-page":"532","article-title":"Observations on transfer of vitamin B12 from mother to fetus and newborn","volume":"96","author":"Luhby AL","year":"1958","journal-title":"American Journal of Disease in Childhood"},{"key":"e_1_2_10_40_2","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1177\/014107688207500814","article-title":"Vitamin B12 deficiency in a breastfed infant of a mother with pernicious anaemia","volume":"75","author":"Hoey H","year":"1982","journal-title":"Journal of the Royal Society of Medicine"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80513-1"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01963568"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992288602500409"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcn031"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-006-0598-7"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2000209"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/48.6.928"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2004.tb00069.x"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.5.1206"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016340500438074"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0902-4441.2006.t01-1-EJH2550.x"},{"key":"e_1_2_10_52_2","first-page":"703","article-title":"Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects","volume":"86","author":"Kirke PN","year":"1993","journal-title":"QJM: An Internation Journal of Medicine"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1173"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.26947B"},{"key":"e_1_2_10_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg043"},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292S117"},{"key":"e_1_2_10_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002470050090"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200404000-00013"},{"key":"e_1_2_10_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0793-y"},{"key":"e_1_2_10_60_2","first-page":"297","volume-title":"Nordic Nutrition Recommendations 2004: Integrating Nutrition and Physical Activity","author":"Nordiska Ministerradet","year":"2004"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292S105"},{"key":"e_1_2_10_62_2","volume-title":"Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids","author":"Food and Nutrition Board, Institute of Medicine","year":"2000"},{"key":"e_1_2_10_63_2","doi-asserted-by":"publisher","DOI":"10.1021\/ba-1982-0200.ch021"},{"key":"e_1_2_10_64_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/32.3.530"},{"key":"e_1_2_10_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8223(94)91950-X"},{"key":"e_1_2_10_66_2","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1093\/jn\/123.6.1054","article-title":"The bioavailability to humans of ascorbic acid from oranges, orange juice and cooked broccoli is similar to that of synthetic ascorbic acid","volume":"123","author":"Mangels AR","year":"1993","journal-title":"Journal of Nutrition"},{"key":"e_1_2_10_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(98)00002-3"},{"key":"e_1_2_10_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/24.4.444"},{"key":"e_1_2_10_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(63)90122-0"},{"key":"e_1_2_10_70_2","first-page":"146","volume-title":"Present Knowledge in Nutrition","author":"Levine M","year":"1996"},{"key":"e_1_2_10_71_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2009.00420.x"},{"key":"e_1_2_10_72_2","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2009.053"},{"key":"e_1_2_10_73_2","doi-asserted-by":"publisher","DOI":"10.1159\/000090495"},{"key":"e_1_2_10_74_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.4.859"},{"key":"e_1_2_10_75_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1989.257.1.C110"},{"key":"e_1_2_10_76_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb26150.x"},{"key":"e_1_2_10_77_2","first-page":"126","article-title":"The total free radical trapping ability of blood plasma in eclampsia","volume":"117","author":"Jendryczko A","year":"1995","journal-title":"Zentralblatt fur Gynakologie"},{"key":"e_1_2_10_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/0271-5317(96)00034-6"},{"key":"e_1_2_10_79_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.104.033381"},{"key":"e_1_2_10_80_2","first-page":"339","article-title":"Vitamins C and E in neonates and their mothers","volume":"45","author":"Tlaskal P","year":"1990","journal-title":"Ceskoslovenska Pediatrie"},{"key":"e_1_2_10_81_2","doi-asserted-by":"publisher","DOI":"10.1177\/1933719110368870"},{"key":"e_1_2_10_82_2","doi-asserted-by":"publisher","DOI":"10.1179\/135100009X392412"},{"key":"e_1_2_10_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2009.02.001"},{"key":"e_1_2_10_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2007.11.006"},{"key":"e_1_2_10_85_2","first-page":"41","article-title":"Micronutrient status in anemic and non\u2010anemic Chinese women in the third trimester of pregnancy","volume":"18","author":"Ma AG","year":"2009","journal-title":"Asia Pacific Journal of Clinical Nutrition"},{"key":"e_1_2_10_86_2","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fdn076"},{"key":"e_1_2_10_87_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.27016"},{"key":"e_1_2_10_88_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp156"},{"key":"e_1_2_10_89_2","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831.74.3.193"},{"key":"e_1_2_10_90_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1961.tb46123.x"},{"key":"e_1_2_10_91_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1965.tb06387.x"},{"key":"e_1_2_10_92_2","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19530052"},{"key":"e_1_2_10_93_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq036"},{"key":"e_1_2_10_94_2","unstructured":"GRADE Working Group.Frequently asked questions.2010[updated 2010];http:\/\/www.gradeworkinggroup.org\/FAQ\/index.htm[last accessed February 2011]."},{"key":"e_1_2_10_95_2","first-page":"177","article-title":"Influence of vitamin B6 on the incidence of preeclampsia","volume":"8","author":"Wachstein M","year":"1956","journal-title":"Obstetrics and Gynecology"},{"key":"e_1_2_10_96_2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/ajcn\/12.6.427","article-title":"Pyridoxine supplementation during pregnancy. Clinical and laboratory observations","volume":"12","author":"Hillman RW","year":"1963","journal-title":"American Journal of Clinical Nutrition"},{"key":"e_1_2_10_97_2","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ajcn\/10.6.512","article-title":"The effects of pyridoxine supplements on the dental caries experience of pregnant women","volume":"10","author":"Hillman RW","year":"1962","journal-title":"American Journal of Clinical Nutrition"},{"key":"e_1_2_10_98_2","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/jn\/114.5.977","article-title":"Effect of maternal pyridoxine X HCl supplementation on the vitamin B\u20106 status of mother and infant and on pregnancy outcome","volume":"114","author":"Schuster K","year":"1984","journal-title":"Journal of Nutrition"},{"key":"e_1_2_10_99_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/29.12.1376"},{"key":"e_1_2_10_100_2","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.45.449"},{"key":"e_1_2_10_101_2","doi-asserted-by":"publisher","DOI":"10.2165\/00126839-200405050-00002"},{"key":"e_1_2_10_102_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-004-0433-y"},{"key":"e_1_2_10_103_2","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/ajcn\/8.4.434","article-title":"Vitamin B6, serum lipids and placental arteriolar lesions in human pregnancy","volume":"8","author":"Swartwout JR","year":"1960","journal-title":"American Journal of Clinical Nutrition"},{"key":"e_1_2_10_104_2","first-page":"CD000179","article-title":"Pyridoxine (vitamin B6) supplementation in pregnancy","volume":"2","author":"Thaver D","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_10_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.02.005"},{"key":"e_1_2_10_106_2","first-page":"538","article-title":"The relationship of neonatal serum vitamin B12 status with birth weight","volume":"15","author":"Muthayya S","year":"2006","journal-title":"Asia Pacific Journal of Clinical Nutrition"},{"key":"e_1_2_10_107_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602383"},{"key":"e_1_2_10_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.01.045"},{"key":"e_1_2_10_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)80010-5"},{"key":"e_1_2_10_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.09.005"},{"key":"e_1_2_10_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68433-X"},{"key":"e_1_2_10_112_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054186"},{"key":"e_1_2_10_113_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000289576.43441.1f"},{"key":"e_1_2_10_114_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2009.02158.x"},{"key":"e_1_2_10_115_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908056"},{"key":"e_1_2_10_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.01.050"},{"key":"e_1_2_10_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60630-7"},{"key":"e_1_2_10_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.07.011"},{"key":"e_1_2_10_119_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181ed721d"},{"key":"e_1_2_10_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(03)00858-5"},{"key":"e_1_2_10_121_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb11979.x"},{"key":"e_1_2_10_122_2","doi-asserted-by":"publisher","DOI":"10.1080\/014436103000074673"},{"key":"e_1_2_10_123_2","doi-asserted-by":"publisher","DOI":"10.3109\/10641950802629667"},{"key":"e_1_2_10_124_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980007001322"},{"key":"e_1_2_10_125_2","first-page":"CD004072","article-title":"Vitamin C supplementation in pregnancy","volume":"7","author":"Rumbold A","year":"2010","journal-title":"The Cochrane Library"},{"key":"e_1_2_10_126_2","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0b013e3182095366"},{"key":"e_1_2_10_127_2","volume-title":"Guidelines for Food Fortification with Micronutrients","author":"Allen LH","year":"2006"}],"container-title":["Paediatric and Perinatal Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3016.2012.01277.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3016.2012.01277.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T21:39:01Z","timestamp":1743629941000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3016.2012.01277.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,28]]},"references-count":126,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1365-3016.2012.01277.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3016.2012.01277.x","archive":["Portico"],"relation":{},"ISSN":["0269-5022","1365-3016"],"issn-type":[{"value":"0269-5022","type":"print"},{"value":"1365-3016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,28]]}}}