{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T07:46:44Z","timestamp":1794469604316,"version":"4.9.1"},"reference-count":91,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:00:00Z","timestamp":1340841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitamin D has well\u2010defined classical functions related to calcium metabolism and bone health but also has non\u2010classical effects that may influence other aspects of health. There has been considerable recent interest in the role of vitamin D on outcomes related to pregnancy and young child health but few efforts have been made to systematically consolidate this evidence to inform the research and policy agenda for low\u2010income countries. A systematic review was undertaken to identify intervention and observational studies of vitamin D supplementation, intake or status (25\u2010hydroxy\u2010vitamin D) during pregnancy on perinatal and infant health outcomes. Data from trials and observational studies isolating the effect of vitamin D supplementation and intake were extracted and study quality was evaluated. Meta\u2010analysis was used to pool effect estimates. We identified five randomised trials with outcomes of relevance to our review. All had small sample size and dosage amount, duration and frequency varied as did the ability to correct deficiency. Pooled analysis of trials using fixed\u2010effects models suggested protective effects of supplementation on low birthweight (three trials, risk ratio (RR)\u2003=\u20030.40 [95% confidence interval (CI) 0.23, 0.71]) and non\u2010significant but suggestive effects of daily supplementation on small\u2010for\u2010gestational age (two trials, RR\u2003=\u20030.67 [0.40, 1.11]). No effect on preterm delivery (&lt;37 weeks) was evident (two trials, RR\u2003=\u20030.77 [0.35, 1.66]). Little evidence from trials exists to evaluate the effect of vitamin D supplementation during pregnancy on maternal, perinatal or infant health outcomes. Based on both trials and observational studies, we recommend that future research explore small\u2010for\u2010gestational age, preterm delivery, pre\u2010eclampsia, and maternal and childhood infections, as outcomes of interest. Trials should focus on populations with a high prevalence of vitamin D deficiency, explore the relevance of timing of supplementation, and the dosage used in such trials should be sufficient to correct deficiency.<\/jats:p>","DOI":"10.1111\/j.1365-3016.2012.01283.x","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T16:30:06Z","timestamp":1340901006000},"page":"75-90","source":"Crossref","is-referenced-by-count":238,"title":["Vitamin D During Pregnancy and Maternal, Neonatal and Infant Health Outcomes: A Systematic Review and Meta\u2010analysis"],"prefix":"10.1111","volume":"26","author":[{"given":"Andrew","family":"Thorne\u2010Lyman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafaie W.","family":"Fawzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,28]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1217"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.3691.595"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.02.002"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2008.00100.x"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.463"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2010.146"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1410358"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2008.14"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/88.2.520S"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.04.070184.002425"},{"key":"e_1_2_9_13_2","volume-title":"Vitamin and Minteral Requirements in Human Nutrition","author":"WHO (World Health Organization)","year":"2004"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.5.1317s"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.6.1752S"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.108.103168"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0b013e3181dbc55b"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1320173"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsgi.2004.02.002"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31819dba91"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-009-0452-9"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215109992684"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003332"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-6-3"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2006.12.097"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0298"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.951"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.6.1748S"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2008.01.033"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02405318"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1479"},{"key":"e_1_2_9_32_2","volume-title":"Dietary Reference Intakes for Calcium and Vitamin D","author":"Institute of Medicine","year":"2011"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.328"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e318214ea2d"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2010.00306.x"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000228.pub2"},{"key":"e_1_2_9_37_2","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/ajcn\/79.5.717","article-title":"Assessment of dietary vitamin D requirements during pregnancy and lactation","volume":"79","author":"Hollis BW","year":"2004","journal-title":"American Journal of Clinical Nutrition"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.07s215"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.122689"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2006519"},{"key":"e_1_2_9_41_2","unstructured":"The Nordic Cochrane Centre TCC. Review Manager (RevMan) Version 5.1. Copenhagen 2011."},{"key":"e_1_2_9_42_2","volume-title":"Statistical Simulation: Power Method Polynomials and Other Transformations","author":"Headrick TC","year":"2010"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03403.x"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1159\/000299597"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03234.x"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1041388"},{"key":"e_1_2_9_47_2","first-page":"488","article-title":"Effect of vitamin D supplementation during pregnancy on foetal growth","volume":"88","author":"Marya RK","year":"1988","journal-title":"Indian Journal of Medical Research"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01352.x"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008770"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1086\/605699"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.003921"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-198609000-00002"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.280.6216.751"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2009.134"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602680"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1391"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03316.x"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1017\/S000711451000022X"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2008.55"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2008.02422.x"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.3.788"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.27097"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.119636"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2008.10.006"},{"key":"e_1_2_9_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-011-0264-x"},{"key":"e_1_2_9_66_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0718"},{"key":"e_1_2_9_67_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0996"},{"key":"e_1_2_9_68_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.158238"},{"key":"e_1_2_9_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02742.x"},{"key":"e_1_2_9_70_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.283.6298.1024"},{"key":"e_1_2_9_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)67922-1"},{"key":"e_1_2_9_72_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0442"},{"key":"e_1_2_9_73_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19900063"},{"key":"e_1_2_9_74_2","doi-asserted-by":"publisher","DOI":"10.1159\/000298772"},{"key":"e_1_2_9_75_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181a70f08"},{"key":"e_1_2_9_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_9_77_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.339"},{"key":"e_1_2_9_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2009.05.005"},{"key":"e_1_2_9_79_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01726.x"},{"key":"e_1_2_9_80_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.1998.770309.x"},{"key":"e_1_2_9_81_2","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181bd9804"},{"key":"e_1_2_9_82_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2010.02578.x"},{"key":"e_1_2_9_83_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2006.tb00205.x"},{"key":"e_1_2_9_84_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.133009"},{"key":"e_1_2_9_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(36)80032-8"},{"key":"e_1_2_9_86_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.1.204"},{"key":"e_1_2_9_87_2","volume-title":"Randomized Pilot Trial of Two Oral Vitamin D3 Supplementation Regimens during the Third Trimester of Pregnancy in Bangladeshi Women: Effects on Neonatal Vitamin D Status and Safety","author":"Roth D","year":"2011"},{"key":"e_1_2_9_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.203"},{"key":"e_1_2_9_89_2","unstructured":"(NIH) USNIoH. Clinicaltrials.gov. 2011;http:\/\/clinicaltrials.gov\/ct2\/results?term=vitamin+D+pregnancy[last accessed May 2012]."},{"key":"e_1_2_9_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2007.03.003"},{"key":"e_1_2_9_91_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02742.x"},{"key":"e_1_2_9_92_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1981.tb01686.x"}],"container-title":["Paediatric and Perinatal Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3016.2012.01283.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3016.2012.01283.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T21:38:00Z","timestamp":1743629880000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3016.2012.01283.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,28]]},"references-count":91,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1365-3016.2012.01283.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3016.2012.01283.x","archive":["Portico"],"relation":{},"ISSN":["0269-5022","1365-3016"],"issn-type":[{"value":"0269-5022","type":"print"},{"value":"1365-3016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,28]]}}}