{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T05:13:52Z","timestamp":1794201232244,"version":"4.8.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T00:00:00Z","timestamp":1337212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sucharew H, Khoury JC, Xu Y, Succop P, Yolton K. NICU Network Neurobehavioral Scale profiles predict developmental outcomes in a low\u2010risk sample. <jats:italic>Paediatric and Perinatal Epidemiology<\/jats:italic> 2012; <jats:bold>\u2022\u2022<\/jats:bold>: \u2022\u2022\u2013\u2022\u2022.<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> Latent profile analysis (LPA) has been used previously to classify neurobehavioral responses of infants prenatally exposed to cocaine and other drugs of abuse. The objective of this study was to define NICU Network Neurobehavioral Scale (NNNS) profile response patterns in a cohort of infants with no known cocaine exposure or other risks for neurobehavior deficits, and determine whether these profiles predict neurobehavioral outcomes in these low\u2010risk infants.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> NNNS exams were performed on 355 low\u2010risk infants at approximately 5 weeks after birth. LPA was used to define discrete profiles based on the standard NNNS summary scales. Associations between the infant profiles and neurobehavioral outcomes at one to three years of age were examined.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Twelve of the 13 summary scales were used and three discrete NNNS profiles identified: social\/easy going infants (44%), hypotonic infants (24%), and high arousal\/difficult infants (32%). Statistically significant associations between NNNS profiles and later neurobehavioral outcomes were found for psychomotor development and externalizing behaviors. Hypotonic infants had both lower psychomotor development and lower externalizing scores compared to the other two profiles.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Three distinct profiles of the NNNS summary scores were identifiable using LPA among infants with no known cocaine exposure. These profile patterns were associated with early childhood neurobehavioral outcome, similar to findings reported in a study of infants with substantial cocaine exposure, demonstrating the utility of this profiling technique in both exposed and unexposed populations.<\/jats:p>","DOI":"10.1111\/j.1365-3016.2012.01288.x","type":"journal-article","created":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T17:21:51Z","timestamp":1337275311000},"page":"344-352","source":"Crossref","is-referenced-by-count":65,"title":["NICU Network Neurobehavioral Scale Profiles Predict Developmental Outcomes in a Low\u2010Risk Sample"],"prefix":"10.1111","volume":"26","author":[{"given":"Heidi","family":"Sucharew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane C.","family":"Khoury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Succop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Yolton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.S2.641"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0204"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1542\/peds.98.1.71","article-title":"Effects of in utero substance exposure on infant neurobehavior","volume":"98","author":"Napiorkowski B","year":"1996","journal-title":"Pediatrics"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.6.1182"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2008.11.004"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2007.09.005"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2009.07.004"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.6.1318"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.07.048"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.3109\/10826084.2010.484474","article-title":"Infant neurobehavior following prenatal exposure to methadone or buprenorphine: results from the neonatal intensive care unit network neurobehavioral scale","volume":"45","author":"Jones HE","year":"2010","journal-title":"Substance Use & Misuse"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2006.12.001"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0880"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.2223\/JPED.1796"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.046276"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/bfm.2008.0120"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/ip.2008.020958"},{"key":"e_1_2_6_18_2","volume-title":"Bayley Scales of Infant Development","author":"Bayley N","year":"1993"},{"key":"e_1_2_6_19_2","volume-title":"Behavior Assessment System for Children","author":"Reynolds CR","year":"2004"},{"key":"e_1_2_6_20_2","volume-title":"Mplus Users' Guide","author":"Muthen L","year":"1998"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/88.3.767"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn301"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.2307\/1390838"}],"container-title":["Paediatric and Perinatal Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3016.2012.01288.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3016.2012.01288.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T06:02:03Z","timestamp":1697263323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3016.2012.01288.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,17]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1365-3016.2012.01288.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3016.2012.01288.x","archive":["Portico"],"relation":{},"ISSN":["0269-5022","1365-3016"],"issn-type":[{"value":"0269-5022","type":"print"},{"value":"1365-3016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,17]]}}}