{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:41:37Z","timestamp":1759992097227},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,10,9]],"date-time":"2007-10-09T00:00:00Z","timestamp":1191888000000},"content-version":"vor","delay-in-days":10174,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[1979,12]]},"abstract":"<jats:p><jats:bold>Summary<\/jats:bold> Mice infected with Schistosoma mansoni were highly sensitive to the lethal effects of bacterial lipopolysaccharide (LPS).The hyper\u2010reactive state of LPS coincided with the development around the parasite eggs of multiple granulomas in the liver. Elevated aspartate transaminase levels in blood and severe hypoglycaemia in LPS\u2010challenged animals indicated extensive liver parenchymal cell damage. There was also a complete depletion of glycogen in hepatocytes of these animals. From this work and studies on other hepatitis models, it is suggested that individuals affected with granulomatous disorders may be at risk because of everyday exposure to LPS from the gut.<\/jats:p>","DOI":"10.1111\/j.1365-3024.1979.tb00714.x","type":"journal-article","created":{"date-parts":[[2007,10,9]],"date-time":"2007-10-09T11:28:57Z","timestamp":1191929337000},"page":"289-294","source":"Crossref","is-referenced-by-count":15,"title":["Increased hepatotoxicity of bacterial lipopolysaccharide in mice infected with Schistosoma mansoni"],"prefix":"10.1111","volume":"1","author":[{"given":"J.","family":"FERLUGA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"DOENHOFF","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.C.","family":"ALLISON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"303","article-title":"Macrophage activation and nonspecific immunity","volume":"18","author":"Allison A.C.","year":"1978","journal-title":"International Review of Experimental Pathology"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-6150-3_7"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91213-6"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92609-0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00005344"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92828-3"},{"key":"e_1_2_1_8_1","first-page":"286","article-title":"Prostaglandin synthesis and phagocytosis\u2010induced chemiluminescence in endotoxin\u2010activated macrophages","volume":"9","author":"Fischer H.","year":"1977","journal-title":"European Surgical Research"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/273759a0"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/258076a0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.36.3.617"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103055"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1128\/iai.7.1.68-75.1973","article-title":"Migration inhibitory factor and interferon in the circulation of mice with delayed hypersensitivity","volume":"7","author":"Salvin S.B.","year":"1973","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-159-40286"},{"key":"e_1_2_1_15_1","first-page":"23","article-title":"Endotoxin\u2010induced hepatic damage in BCG\u2010infected mice","volume":"67","author":"Shands Jr. J.W.","year":"1972","journal-title":"American Journal of Pathology"},{"key":"e_1_2_1_16_1","first-page":"354","article-title":"Hyperreactivity to endotoxin in mice infected with mycobacteria: induction and elicitation of the reactions","volume":"4","author":"Suter E.","year":"1961","journal-title":"Immunology"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.22.2.246-b"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/273609a0"},{"key":"e_1_2_1_19_1","first-page":"1015","volume-title":"Mononuclear Phagocytes in Immunity, Infection and Pathology","author":"Warren K.S.","year":"1975"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3024.1979.tb00714.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3024.1979.tb00714.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T17:25:07Z","timestamp":1699637107000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3024.1979.tb00714.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,12]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1979,12]]}},"alternative-id":["10.1111\/j.1365-3024.1979.tb00714.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3024.1979.tb00714.x","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,12]]}}}