{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T08:13:06Z","timestamp":1758269586074},"reference-count":0,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T00:00:00Z","timestamp":1223510400000},"content-version":"vor","delay-in-days":3753,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[1998,7]]},"abstract":"<jats:p> <jats:italic>We compared temporal changes in the cell composition of the skin\u2010draining lymph nodes (SLN) in guinea\u2010pigs exposed percutaneously to normal or attenuated cercariae of <\/jats:italic>Schistosoma mansoni<jats:italic>. Different populations were analysed by flow cytometry of double\u2010stained cells by monoclonal antibodies to the major histocompatibility complex class II molecule and lymph node cells of guinea\u2010pigs. Exposure to <\/jats:italic>S. mansoni<jats:italic> caused a marked increase in the proportion of B cells and dendritic cells (DC) on day 2, reaching a peak number on day 4. These changes were comparable in both infected and vaccinated animals exposed to normal or attenuated parasites, respectively. Total number of DC, however, showed different kinetics; in infected animals, the number peaked on day 2 and then gradually declined, whereas it reached a higher peak on day 4 in vaccinated animal. Daily injection of bromo\u2010deoxyuridine after exposure to the parasite reduced the total number of DC in the SLN on day 4. A reduction in DC counts in the contralateral side SLN was also evident in vaccinated animals. Our results indicate that a significant number of newly formed DC are recruited to the skin by 4th day of vaccination, followed by increased efflux to the SLN. It is possible that retention of attenuated <\/jats:italic>S. mansoni<jats:italic> in the skin may cause accelerated recruitment of newly formed DC from the bone marrow, and facilitate transport and processing of antigens highly expressed on attenuated parasites.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1365-3024.1998.158.x","type":"journal-article","created":{"date-parts":[[2007,4,25]],"date-time":"2007-04-25T08:26:53Z","timestamp":1177489613000},"page":"337-343","source":"Crossref","is-referenced-by-count":8,"title":["Accelerated influx of dendritic cells into the lymph nodes draining skin sites exposed to attenuated cercariae of <i>Schistosoma mansoni<\/i> in guinea\u2010pigs"],"prefix":"10.1111","volume":"20","author":[{"given":"H.","family":"SATO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"KAMIYA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,9]]},"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3024.1998.158.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3024.1998.158.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3024.1998.158.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T22:51:14Z","timestamp":1694299874000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3024.1998.158.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,7]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1998,7]]}},"alternative-id":["10.1111\/j.1365-3024.1998.158.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3024.1998.158.x","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,7]]}}}