{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T22:24:11Z","timestamp":1781821451948,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,2,25]],"date-time":"2004-02-25T00:00:00Z","timestamp":1077667200000},"content-version":"vor","delay-in-days":147,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p><jats:italic>The interaction between <\/jats:italic>Schistosoma mansoni <jats:italic>and platelets of non\u2010immune mice has been studied<\/jats:italic> in vivo<jats:italic> and <\/jats:italic>in vitro<jats:italic>. A moderate thrombocytopaenia was observed in mice 2\u00a0days after they had been infected percutaneously with 200 cercariae. A rabbit anti\u2010mouse platelet antiserum, 25\u00a0\u00b5L of which injected subcutaneously induced a nearly 90% reduction in blood platelet count 24\u00a0h later, was used to investigate the effects of severe thrombocytopaenia on <\/jats:italic>S.\u00a0mansoni<jats:italic> infections. In replicate experiments worm burdens were significantly increased in mice that were thrombocytopaenic at the time of infection when compared with untreated mice. Induction of thrombocytopaenia on day 4 after infection had no effect on worm count. Platelets isolated from non\u2010immune mice were shown to adhere to the surfaces of and kill mechanically transformed schistosomula <\/jats:italic>in vitro<jats:italic>. Platelets may thus be an innate mechanism of defence against schistosome infection, and the thrombocytopaenia that occurs during patent schistosome infections may be a strategy that helps secondarily incoming parasites evade this type of host defensiveness.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1365-3024.2003.00656.x","type":"journal-article","created":{"date-parts":[[2004,2,25]],"date-time":"2004-02-25T17:21:27Z","timestamp":1077729687000},"page":"467-473","source":"Crossref","is-referenced-by-count":24,"title":["Platelets as an innate defence mechanism against <i>Schistosoma mansoni<\/i> infections in mice"],"prefix":"10.1111","volume":"25","author":[{"given":"Ronald G.","family":"Stanley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justinian R.","family":"Ngaiza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Wambayi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Doenhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,2,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(87)90444-5"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-193-42993"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182002002858"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/303810a0"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-8326-0_2"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000234703"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000086248"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00005344"},{"key":"e_1_2_6_10_2","first-page":"328","article-title":"Conditions affecting the accuracy of potasium hydroxide digestion techniques for counting Schistosoma mansoni eggs in tissues","volume":"39","author":"Cheever AW.","year":"1968","journal-title":"Bull WHO"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000054731"},{"key":"e_1_2_6_12_2","first-page":"365","article-title":"Morphology and enumeration of human blood platelets","volume":"3","author":"Brecher G","year":"1950","journal-title":"Am J Physiol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182097001303"},{"key":"e_1_2_6_14_2","first-page":"309","volume-title":"Platelets in Biology and Pathology \u2013 2","author":"Polley MJ","year":"1981"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000073479"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000000731"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X0002664X"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000050253"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1984.33.89"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000064118"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1986.tb01038.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.12.6524-6533.2002"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1006\/expr.2000.4517"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.1.65"},{"key":"e_1_2_6_25_2","unstructured":"NgaizaJR.Platelet studies in the host\u2010parasite relationship ofSchistosoma mansoniinfections in mice1988:PhD Thesis. University of London."}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3024.2003.00656.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3024.2003.00656.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T00:16:51Z","timestamp":1697242611000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3024.2003.00656.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["10.1111\/j.1365-3024.2003.00656.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3024.2003.00656.x","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10]]}}}