{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T23:16:09Z","timestamp":1794438969755,"version":"4.9.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,6]],"date-time":"2005-05-06T00:00:00Z","timestamp":1115337600000},"content-version":"vor","delay-in-days":66,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Pigs single inoculated with<\/jats:italic>\n                    Ascaris suum\n                    <jats:italic>eggs expel the majority of larvae between days 14 and 21 post inoculation (p.i.), but the role of the immune system in expulsion is unclear. To investigate the dynamics of immune responses before, during and after the expulsion of<\/jats:italic>\n                    A.\u00a0suum\n                    <jats:italic>larvae, pigs inoculated with 10\u00a0000<\/jats:italic>\n                    \u00a0A.\u00a0suum\n                    <jats:italic>eggs were sequentially necropsied.<\/jats:italic>\n                    Ascaris suum\n                    <jats:italic>gradually moved distally from days 10\u201314 p.i. and only a few larvae were left by day 21 p.i. Pronounced increases in mucosal<\/jats:italic>\n                    A.\u00a0suum\n                    <jats:italic>\u2010specific IgA antibody secreting cells (ASCs) were already found by day 10 p.i. especially in the proximal jejunum, while only small increases in parasite\u2010specific IgM ASCs were observed by day 21 p.i. in both proximal and distal jejunum. No mucosal IgG ASC responses could be detected. Increases in systemic<\/jats:italic>\n                    A.\u00a0suum\n                    <jats:italic>\u2010specific IgG1, IgM and to a lesser extent IgA antibodies were observed, while IgG2 remained almost unchanged. The levels of eosinophils and mast cells in the small intestinal mucosa did not change throughout infection. The results demonstrate that both systemic and mucosal<\/jats:italic>\n                    A.\u00a0suum\n                    <jats:italic>\u2010specific effector mechanisms are strongly stimulated in<\/jats:italic>\n                    A.\u00a0suum\n                    <jats:italic>single infections and indicate that mucosal IgA may be an important mediator in the expulsion of<\/jats:italic>\n                    A.\u00a0suum\n                    <jats:italic>.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1111\/j.1365-3024.2005.00752.x","type":"journal-article","created":{"date-parts":[[2005,5,6]],"date-time":"2005-05-06T05:05:59Z","timestamp":1115355959000},"page":"79-88","source":"Crossref","is-referenced-by-count":38,"title":["Host immune reactions and worm kinetics during the expulsion of\n                    <i>Ascaris suum<\/i>\n                    in pigs"],"prefix":"10.1111","volume":"27","author":[{"given":"N.","family":"Miquel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Roepstorff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Eriksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(94)90084-1"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.2307\/3285733"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1645\/0022-3395(2000)086[0421:DOCSDT]2.0.CO;2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.2307\/3284450"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2307\/3277198"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182097001480"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(80)90051-X"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(97)00223-9"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(88)90051-3"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(92)90017-4"},{"key":"e_1_2_6_12_2","volume-title":"Host Parasite Relations in Ascaris suum Infection in Pigs and Mice.","author":"Eriksen L","year":"1981"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(88)90122-7"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(89)90165-9"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1999.00261.x"},{"key":"e_1_2_6_16_2","first-page":"577","article-title":"Production of cytokines by lymphocytes from spleen, mesenteric lymph node and intestinal lamina propria of pigs","volume":"82","author":"Bailey M","year":"1994","journal-title":"Immunology"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(82)90022-8"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(02)00347-3"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000236456"},{"key":"e_1_2_6_20_2","volume-title":"Klinisk Laboratorium\u2010Teknik (Clinical Laboratory Technique)","author":"Astrup PB","year":"1959"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-82-20190"},{"key":"e_1_2_6_22_2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1186\/BF03547520","article-title":"Embryonation and infectivity of Ascaris suum eggs. A comparison of eggs collected from worm uteri with eggs isolated from pig faeces","volume":"31","author":"Oksanen A","year":"1990","journal-title":"Acta Vet Scand"},{"key":"e_1_2_6_23_2","volume-title":"The Epidemiology, Diagnosis and Control of Helminth Parasites of Swine.","author":"Roepstorff A","year":"1988"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/BF03548483"},{"key":"e_1_2_6_25_2","volume-title":"Handbook of Mucosal Immunology.","author":"Phillips\u2010Quagliata JM","year":"1994"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(71)90107-X"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-002-0458-4"},{"key":"e_1_2_6_28_2","first-page":"233","article-title":"Experimental Ascaris suum infection in pigs \u2013 Serological response, eosinophilia in peripheral blood, occurrence of white spots in the liver and worm recovery from the intestine","volume":"32","author":"Eriksen L","year":"1980","journal-title":"Nord Vet Med"},{"key":"e_1_2_6_29_2","first-page":"1604","article-title":"Immune\u2010responses of swine to oral inoculation with embryonated eggs of Ascaris suum","volume":"43","author":"Rhodes MB","year":"1982","journal-title":"Am J Vet Res"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1999.00200.x"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.13.5513"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.149.11.3642"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2787531"},{"key":"e_1_2_6_34_2","first-page":"177","article-title":"Experimentally induced resistance to Ascaris suum in pigs","volume":"34","author":"Eriksen L","year":"1982","journal-title":"Nord Vet Med"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182098003382"},{"key":"e_1_2_6_36_2","unstructured":"CoatesS.Modelling the population dynamics ofAscaris suumin pigs.PhD Thesis.Copenhagen Denmark Danish Centre for Experimental Parasitology and Coventry United Kingdom The University of Warwick 2000."}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3024.2005.00752.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3024.2005.00752.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T10:22:49Z","timestamp":1696933369000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3024.2005.00752.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["10.1111\/j.1365-3024.2005.00752.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3024.2005.00752.x","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}