{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:53:03Z","timestamp":1790013183063,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T00:00:00Z","timestamp":1147737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p> <jats:italic>Eosinophils are locally recruited during the establishment and chronic phases of cystic hydatidosis. This study provides evidence that eosinophil cationic protein (ECP), one of the major components of eosinophil granules, can damage<\/jats:italic> Echinococcus granulosus <jats:italic>protoscoleces (PSC). The toxicity of ECP was investigated<\/jats:italic> in vitro <jats:italic>by following parasite viability in the presence of this protein. ECP was found to damage PSC at micromolar concentrations; the effect was blocked by specific antibodies and heparin, and was more severe than the one caused by similar concentrations of RNase A, suggesting that the cationic nature of ECP, and not its ribonuclease activity, is involved in toxicity. This observation may highlight the capacity of eosinophils to control secondary hydatidosis, derived from PSC leakage from a primary cyst. To further assess the relevance of the previous result during infection, the presence of eosinophil proteins was investigated in human hydatid cysts. ECP was found to be strongly associated with the laminated layer of the cyst wall, and present at micromolar concentrations in the hydatid fluid. Overall, these results demonstrate that eosinophils degranulate<\/jats:italic> in vivo <jats:italic>at the host\u2013parasite interface, and that the released ECP reaches concentrations that could be harmful for the parasite.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1365-3024.2006.00842.x","type":"journal-article","created":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T15:03:53Z","timestamp":1147791833000},"page":"347-355","source":"Crossref","is-referenced-by-count":23,"title":["Eosinophil cationic protein damages protoscoleces <i>in vitro<\/i> and is present in the hydatid cyst"],"prefix":"10.1111","volume":"28","author":[{"given":"A. L.","family":"RAMOS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. G.","family":"DISCIPIO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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