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Such a wide range of immunomodulation caused by helminthes may have an impact on the host's ability to cope with subsequent infections and\/or may affect the efficacy of vaccination. Indeed studies conducted in humans living in helminth\u2010endemic areas and in animal models showed that helminth infection makes the host more permissive to mycobacterial infections and less able to benefit from vaccination. These observations have fundamental practical consequences if confirmed by large and appropriately controlled clinical studies. Eradication of worms could offer an affordable, simple and novel means to reduce the burden of the tuberculosis problem that at the moment seems to be getting out of control in sub\u2010Saharan Africa. This information would also be of great relevance in the design of vaccines against diseases of major public health importance, including malaria and HIV\/AIDS.<\/jats:italic> <\/jats:p>","DOI":"10.1111\/j.1365-3024.2006.00854.x","type":"journal-article","created":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T13:11:55Z","timestamp":1145970715000},"page":"507-513","source":"Crossref","is-referenced-by-count":59,"title":["Helminthes could influence the outcome of vaccines against TB in the tropics"],"prefix":"10.1111","volume":"28","author":[{"given":"D.","family":"ELIAS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"AKUFFO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"BRITTON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,25]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"WHO.Global Tuberculosis Control: Surveillance Planning Financing.WHO report. 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