{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:06:27Z","timestamp":1791198387980,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,5,10]],"date-time":"2006-05-10T00:00:00Z","timestamp":1147219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p> <jats:italic>Ocular toxoplasmosis (OT) can occur in the children of mothers infected with<\/jats:italic> Toxoplasma gondii <jats:italic>during pregnancy. It is not limited to the congenitally infected, but can also occur following adult\u2010acquired infection or as a result of disease reactivation in immune\u2010compromised and pregnant individuals. Many aspects of immune privilege in the eye, including constitutive TGF\u2010\u03b2 expression and reduced MHC class 1 expression, would appear at first to favour parasite survival. Conversely, many of the mechanisms that control parasite multiplication in other anatomical sites, such as nitric oxide expression, IFN\u2010\u03b3 and TNF\u2010\u03b1, are known to disrupt immune privilege and are associated with ocular damage. Taking into account the opposing needs of limiting parasite multiplication and minimizing tissue destruction we review the pathogenesis of OT in the murine model.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1365-3024.2006.00874.x","type":"journal-article","created":{"date-parts":[[2006,5,10]],"date-time":"2006-05-10T08:44:03Z","timestamp":1147250643000},"page":"635-642","source":"Crossref","is-referenced-by-count":61,"title":["Ocular toxoplasmosis: in the storm of the eye"],"prefix":"10.1111","volume":"28","author":[{"given":"L. A.","family":"JONES","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"ALEXANDER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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