{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:34:41Z","timestamp":1756312481099},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,5,30]],"date-time":"2006-05-30T00:00:00Z","timestamp":1148947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p> <jats:italic>The heart can be seriously affected in human trichinellosis, and cardiac involvement can cause death. Experimental infections in rats have suggested the possible participation of immunopathological processes. The aim of the present paper was to investigate the possible presence in trichinellosis patient sera of antibodies recognizing host tissues and particularly the myocardium. Nineteen sera from late period trichinellosis patients, who acquired infection in the Poznan region (Poland), were tested by immunoblot on extracts from normal rat or human heart ventricle wall, spleen, placenta, kidney and skeletal muscle. Patients\u2019 sera recognized several antigens that were not recognized by normal sera. On rat and human heart ventricle wall, a high proportion of sera (42%) reacted with a protein of 68\u00a0kDa (<\/jats:italic>P\u00a0&lt;\u00a0<jats:italic>0\u00b705 compared to normal sera). The reactivity with this antigen, however, was not significantly different in patients with or without cardiac involvement. When sera were tested on skeletal muscle we found that 47% reacted with a protein of 27\u00a0kDa and 53% reacted with a protein of 41\u00a0kDa (<\/jats:italic>P\u00a0&lt;\u00a0<jats:italic>0\u00b705 for both proteins, compared with normal sera). The reactivity against the 68\u00a0kDa antigen and against the 27 and 41\u00a0kDa skeletal muscle antigens was not observed on kidney, placenta and spleen extracts. Moreover, very few bands were observed on these tissues as compared to heart and skeletal muscle tissues, thus suggesting a high tissue specificity of the reactivity of trichinellosis sera. In conclusion, this study identifies organ\u2010specific autoantibodies in trichinellosis patient sera, their role in the pathogenesis of cardiac involvement being still unclear.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1365-3024.2006.00889.x","type":"journal-article","created":{"date-parts":[[2006,5,30]],"date-time":"2006-05-30T12:28:13Z","timestamp":1148992093000},"page":"447-451","source":"Crossref","is-referenced-by-count":15,"title":["Heart\u2010 and skeletal muscle\u2010specific antigens recognized by trichinellosis patient sera"],"prefix":"10.1111","volume":"28","author":[{"given":"F.","family":"PRATESI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"BONGIORNI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"KOCIECKA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"MIGLIORINI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"BRUSCHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(00)00132-6"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(00)00341-1"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.78.915.15"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.3.8.1117"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.3.603"},{"key":"e_1_2_6_7_2","volume-title":"Trichinosis in Man and Animals.","author":"Gould SE","year":"1970"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050164"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/200108s2147"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02317.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","DOI":"10.1201\/b12594","volume-title":"Parasites: Immunity and Pathology","author":"Behnke JM","year":"1990"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2003.08.008"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4922(02)00006-5"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/08830189209055574"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.6.3410-3417.2004"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568008023340523"},{"key":"e_1_2_6_17_2","first-page":"793","article-title":"Development and evaluation of a Western blot kit for diagnosis of human trichinellosis","volume":"10","author":"Yera H","year":"2003","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.13.1255"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830230525"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425147"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3024.2006.00889.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3024.2006.00889.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T18:44:30Z","timestamp":1696877070000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3024.2006.00889.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,9]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1365-3024.2006.00889.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3024.2006.00889.x","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,9]]}}}