{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T05:10:36Z","timestamp":1696914636032},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,9,29]],"date-time":"2006-09-29T00:00:00Z","timestamp":1159488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p> <jats:italic>BALB\/c mice are highly susceptible to African trypanosomiasis, whereas C57BL\/6 mice are relatively resistant. Other investigators have reported that the synthesis of IgG antibodies to purified membrane form of variant surface glycoprotein (mfVSG) of<\/jats:italic> Trypanosoma brucei <jats:italic>is CD1 restricted. In this study, we examine the role of the CD1d\/NKT cell pathway in susceptibility and resistance of mice to infection by African trypanosomes<\/jats:italic>. <jats:italic>Administration of anti\u2010CD1d antibodies to<\/jats:italic> Trypanosoma congolense<jats:italic>\u2010infected BALB\/c mice neither affects the parasitemia nor the survival time. Correspondingly, CD1d<\/jats:italic><jats:sup><jats:italic>\u2013\/\u2013<\/jats:italic><\/jats:sup><jats:italic> and CD1d<\/jats:italic><jats:sup><jats:italic>+\/+<\/jats:italic><\/jats:sup><jats:italic> BALB\/c mice infected with<\/jats:italic> T. congolense <jats:italic>or<\/jats:italic> T. brucei <jats:italic>show no differences in either parasitaemia or survival time. The course of disease in relative resistant C57BL\/6 mice infected with<\/jats:italic> T. congolense <jats:italic>is also not affected by the absence of CD1d. Parasitaemia, survival time, and plasma levels of IgG2a and IgG3 parasite\u2010specific antibodies in infected CD1d<\/jats:italic><jats:sup><jats:italic>\u2013\/\u2013<\/jats:italic><\/jats:sup><jats:italic> C57BL\/6 are not different from those of infected CD1d<\/jats:italic><jats:sup><jats:italic>+\/+<\/jats:italic><\/jats:sup><jats:italic> C57BL\/6 mice. We conclude that CD1d\u2010restricted immune responses do not play an important role in susceptibility\/resistance of mice infected with virulent African trypanosomes. We speculate that virulent trypanosomes have an evasion mechanism that prevents the induction of a parasite\u2010specific, CD1d\u2010restricted immune response by the host.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1365-3024.2006.00898.x","type":"journal-article","created":{"date-parts":[[2006,9,29]],"date-time":"2006-09-29T15:56:45Z","timestamp":1159545405000},"page":"643-647","source":"Crossref","is-referenced-by-count":5,"title":["Experimental African trypanosomiasis: lack of effective CD1d\u2010restricted antigen presentation"],"prefix":"10.1111","volume":"28","author":[{"given":"M. Q.","family":"SHI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010R.","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. J.","family":"WEI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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