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IL\u20104 protein levels decreased while IL\u201013 levels increased in a 50\u2010worm infection by 30\u00a0dpi; the converse was seen with a five\u2010worm infection. A negative correlation was found between IL\u20104 or IL\u201013 mRNA expression and worm biomass, between IL\u201013 protein levels and worm number or worm biomass, and between IL\u20104 protein levels and worm biomass in 50\u2010worm infections. A negative correlation between IL\u20104 mRNA or protein expression and worm biomass was observed with five\u2010worm infections. A strong correlation between Muc2 mRNA expression and decreased worm number or biomass in a 50\u2010worm infection was observed. Muc2 protein, goblet cell numbers and mucin decreased in a 50\u2010worm infection by 20\u00a0days post\u2010infection. These changes were not seen with five\u2010worm infections where worms are not expelled. The data show that rats infected with 50<\/jats:italic>\u00a0H.\u00a0diminuta <jats:italic>mount a Th2 response leading to high levels of IL\u201013, increased goblet cell numbers and increased mucin2 production and release. The mucus traps the worms, which are progressively expelled from the small intestine.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1365-3024.2006.00908.x","type":"journal-article","created":{"date-parts":[[2006,9,22]],"date-time":"2006-09-22T13:15:22Z","timestamp":1158930922000},"page":"11-21","source":"Crossref","is-referenced-by-count":45,"title":["Expulsion of the gastrointestinal cestode, <i>Hymenolepis diminuta<\/i> by tolerant rats: evidence for mediation by a Th2 type immune enhanced goblet cell hyperplasia, increased mucin production and secretion"],"prefix":"10.1111","volume":"29","author":[{"given":"R. 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