{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:21:03Z","timestamp":1762078863989},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T00:00:00Z","timestamp":1166140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p> <jats:italic>Epidemiological evidence has led to the hypothesis that the concurrent and predominant transmission of<\/jats:italic> Onchocerca ochengi <jats:italic>by<\/jats:italic> Simulium damnosum <jats:italic>s.l.<\/jats:italic><jats:italic> in sub\u2010Saharan Africa could lead to the protection of humans against onchocerciasis caused by<\/jats:italic> Onchocerca volvulus <jats:italic>(zooprophylaxis). To gain support for this hypothesis, we investigated whether exposure to<\/jats:italic> O.\u00a0volvulus <jats:italic>could protect cattle from<\/jats:italic> O.\u00a0ochengi<jats:italic>. Gudali calves were vaccinated with live<\/jats:italic> O.\u00a0volvulus<jats:italic>\u2010infective larvae and subsequently challenged with<\/jats:italic> O.\u00a0ochengi\u2010<jats:italic>infective larvae whilst raised in a fly\u2010proof house. Post\u2010challenge adult parasite and microfilaria development, IgG1 and lgG2 subclass antibodies response to Ov10\/Ov11 recombinant<\/jats:italic> Onchocerca <jats:italic>antigens, and peripheral blood lymphocyte proliferative responses to<\/jats:italic> O.\u00a0ochengi <jats:italic>crude antigens were studied over a 1\u2010year period. The vaccinated\u2010challenged animals had 83\u201387% less adult<\/jats:italic> O.\u00a0ochengi <jats:italic>parasites than non\u2010vaccinated\u2010challenged animals. IgG1 and lgG2 antibodies to Ov10\/Ov11 recombinant<\/jats:italic> Onchocerca <jats:italic>antigens were invoked by non\u2010vaccinated\u2010challenged animals but not by most (80%) of the vaccinated\u2010challenged animals. These findings support the idea of cross\u2010protection (zooprophylaxis) due to inoculation of humans with<\/jats:italic> O.\u00a0ochengi<jats:italic>\u2010infective larvae under natural transmission conditions in endemic areas.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1365-3024.2006.00917.x","type":"journal-article","created":{"date-parts":[[2006,12,16]],"date-time":"2006-12-16T02:48:20Z","timestamp":1166237300000},"page":"113-116","source":"Crossref","is-referenced-by-count":26,"title":["Successful vaccination against <i>Onchocerca ochengi<\/i> infestation in cattle using live <i>Onchocerca volvulus<\/i> infective larvae"],"prefix":"10.1111","volume":"29","author":[{"given":"M. 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