{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:29:01Z","timestamp":1791044941934,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,10,10]],"date-time":"2006-10-10T00:00:00Z","timestamp":1160438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p> <jats:italic>T helper type 2 (Th2) responses have been shown to be important in protective responses to gastrointestinal (GI) helminth infections and in the development of the intestinal pathology accompanying expulsion of the parasite. Different inbred mouse strains have been shown to develop different cytokine profiles following infection with GI helminths with increased resistance observed in those strains where Th2 cytokines predominate. The aim of this study was to determine the role of IL\u20104, IL\u201013 and IL\u20104R\u03b1 and the impact of host background on the development of the protective and pathological responses induced by infection with the gastrointestinal helminth<\/jats:italic> Trichinella spiralis<jats:italic>. IL\u20104, IL\u201013 and IL\u20104R\u03b1 were required for the generation of Th2 responses to<\/jats:italic> T.\u00a0spiralis; <jats:italic>however, the role these responses play in the development of protection and enteropathy was less clear. IL\u20104R\u03b1\u2010deficiency mice resulted in substantially reduced parasite expulsion, intestinal pathology and Th2 responses. Similarly, lack of IL\u201013 resulted in inhibited expulsion and the development of enteropathy. Although Th2 responses were reduced in BALB\/c IL\u20104\u2013\/\u2013 mice, neither expulsion nor enteropathy were different from wild\u2010type mice. In contrast, C57BL\/6 IL\u20104\u2013\/\u2013 exhibited delayed expulsion and reduced pathology, suggesting that host genetics are important in the function of individual cytokines. Thus, differences in background genotype may be an important component in the development host protection and the development of intestinal pathology accompanying the loss of GI helminths.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1365-3024.2006.00920.x","type":"journal-article","created":{"date-parts":[[2006,10,10]],"date-time":"2006-10-10T16:15:36Z","timestamp":1160496936000},"page":"81-91","source":"Crossref","is-referenced-by-count":54,"title":["The role of IL\u20104, IL\u201013 and IL\u20104R\u03b1 in the development of protective and pathological responses to <i>Trichinella spiralis<\/i>"],"prefix":"10.1111","volume":"29","author":[{"given":"H. E.","family":"SCALES","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. X.","family":"IERNA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. E.","family":"LAWRENCE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.001045"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.1.347"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000053833"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5397.2261"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.9.5864"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80477-X"},{"key":"e_1_2_7_8_2","doi-asserted-by":"crossref","first-page":"7086","DOI":"10.4049\/jimmunol.151.12.7086","article-title":"IFN inhibits inflammatory responses and protective immunity in mice infected with the nematode parasite, Nippostrongylus brasiliensis","volume":"151","author":"Urban JF","year":"1993","journal-title":"J Immunol"},{"key":"e_1_2_7_9_2","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.4049\/jimmunol.154.9.4675","article-title":"IL\u20104 treatment can cure established gastrointestinal nematode infections in immunocompetent and immunodeficient mice","volume":"154","author":"Urban JF","year":"1995","journal-title":"J Immunol"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.4049\/jimmunol.160.7.3453","article-title":"A critical role for IL\u201013 in resistance to intestinal nematode infection","volume":"160","author":"Bancroft AJ","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199809)28:09<2672::AID-IMMU2672>3.0.CO;2-F"},{"key":"e_1_2_7_12_2","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.4049\/jimmunol.163.12.6448","article-title":"Aluminium hydroxide adjuvant initiates strong antigen\u2010specific Th2 responses in the absence of IL\u20104\u2010 or IL\u201013\u2010mediated signaling","volume":"163","author":"Brewer JM","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(98)70256-8"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.2.399"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.2.1063"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.8.4630"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.5.2585"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.supplement_2.2106070"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80439-2"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2001.00353.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.10.1541"},{"key":"e_1_2_7_22_2","first-page":"232","article-title":"Cellular immune responses to the murine nematode parasite Trichuris muris. II. Differential induction of TH\u2010cell subsets in resistant versus susceptible mice","volume":"75","author":"Else KJ","year":"1992","journal-title":"Immunology"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/pim.1993.15.10.595"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.2.1092"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.3.1127"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0141-9838.2004.00686.x"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.12.7302"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(98)70134-4"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.12.1849"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000080173"},{"key":"e_1_2_7_31_2","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1128\/iai.58.12.3863-3870.1990","article-title":"Patterns of cytokine secretion in murine leishmaniasis: correlation with disease progression or resolution","volume":"58","author":"Boom WH","year":"1990","journal-title":"Infect Immun"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000061552"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1108661"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1079\/JOH2003175"},{"key":"e_1_2_7_35_2","first-page":"329","article-title":"Host protective immunity to Trichinella spiralis in mice: activation of Th cell subsets and lymphokine secretion in mice expressing different response phenotypes","volume":"74","author":"Grencis RK","year":"1991","journal-title":"Immunology"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.4.2046"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.8.4804-4807.2003"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324510"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2000.00344.x"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.8.4229"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200007)30:7<2083::AID-IMMU2083>3.0.CO;2-3"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/8.4.559"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.04.004"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.5.643"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.11.6751"},{"key":"e_1_2_7_46_2","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.4049\/jimmunol.156.10.3925","article-title":"Down\u2010regulation by IL\u20104 and up\u2010regulation by IFN\u2010gamma of mast cell induction from mouse spleen cells","volume":"156","author":"Hu ZQ","year":"1996","journal-title":"J Immunol"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1383"},{"key":"e_1_2_7_48_2","first-page":"1103","article-title":"IL\u201013R (alpha) 2, a decoy receptor for IL\u201013 acts as an inhibitor of IL4\u2010dependent signal transduction in glioblastoma cells","volume":"62","author":"Rahaman SO","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.5.3207"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3024.2006.00920.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3024.2006.00920.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T18:48:26Z","timestamp":1696877306000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3024.2006.00920.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,10]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1365-3024.2006.00920.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3024.2006.00920.x","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,10]]}}}