{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:56:47Z","timestamp":1791262607635,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T00:00:00Z","timestamp":1166140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p> <jats:italic>BALB\/c mice are highly susceptible and C57BL\/6 relatively resistant to<\/jats:italic> Trypanosoma congolense <jats:italic>infections. Here we show that relatively resistant wild\u2010type B6 mice infected with<\/jats:italic> T.\u00a0congolense <jats:italic>survive significantly longer (&gt;\u00a0200\u00a0days) than infected major histocompatibility complex (MHC) class II\u2010deficient B6 mice (\u223c50\u00a0days). We also show that blocking of the interleukin\u201010 (IL\u201010) receptor induces early death of wild\u2010type B6 mice infected with<\/jats:italic> T.\u00a0congolense <jats:italic>(\u223c10\u00a0days), but does not affect the survival of infected MHC class II\u2010deficient B6 mice. We conclude that MHC class II\u2010restricted immune responses mediate protection and, when IL\u201010 function is impaired, MHC class II\u2010restricted immune responses mediate early mortality in otherwise resistant B6 mice. Thus, in<\/jats:italic> T.\u00a0congolense <jats:italic>infections, MHC class II\u2010restricted immune responses mediate either protection or disease, depending on IL\u201010 function.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1365-3024.2006.00925.x","type":"journal-article","created":{"date-parts":[[2006,12,16]],"date-time":"2006-12-16T02:48:20Z","timestamp":1166237300000},"page":"107-111","source":"Crossref","is-referenced-by-count":14,"title":["<i>Trypanosoma congolense<\/i> infections: MHC class II\u2010restricted immune responses mediate either protection or disease, depending on IL\u201010 function"],"prefix":"10.1111","volume":"29","author":[{"given":"M. Q.","family":"SHI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. J.","family":"WEI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"TABEL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,15]]},"reference":[{"key":"e_1_2_3_2_2","volume-title":"The African Trypanosomiases","author":"Mulligan HW","year":"1970"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.08.040190.000503"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1996.0451"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.44.1.107-111.1984"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.2307\/3284033"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(00)01318-6"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003350010133"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0697-194"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.20.3.714-720.1978"},{"key":"e_1_2_3_11_2","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.4049\/jimmunol.136.4.1427","article-title":"Mechanisms of self\u2010cure from Trypanosoma congolense infection in mice","volume":"136","author":"Pinder M","year":"1986","journal-title":"J Immunol"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.58.7.2337-2342.1990"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.3.1724"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.11.009"},{"key":"e_1_2_3_15_2","doi-asserted-by":"crossref","first-page":"6775","DOI":"10.4049\/jimmunol.161.12.6775","article-title":"Resistance to the African trypanosomes is IFN\u2010gamma dependent","volume":"161","author":"Hertz CJ","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/320731"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/immu.200390013"},{"key":"e_1_2_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.12.8393-8396.2005"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.10.5507"},{"key":"e_1_2_3_20_2","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.4049\/jimmunol.150.7.2910","article-title":"Characterization of T helper cell responses to the trypanosome variant surface glycoprotein","volume":"150","author":"Schleifer KW","year":"1993","journal-title":"J Immunol"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5399.225"},{"key":"e_1_2_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2006.00898.x"},{"key":"e_1_2_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1982.tb00444.x"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.4.1006"},{"key":"e_1_2_3_25_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1003500"},{"key":"e_1_2_3_26_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.139.1.103"},{"key":"e_1_2_3_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5356.1541"},{"key":"e_1_2_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/cge.1999.21.2.57"},{"key":"e_1_2_3_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3107127"},{"key":"e_1_2_3_30_2","doi-asserted-by":"publisher","DOI":"10.1086\/503808"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3024.2006.00925.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3024.2006.00925.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T18:48:50Z","timestamp":1696877330000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3024.2006.00925.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,15]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1365-3024.2006.00925.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3024.2006.00925.x","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,15]]}}}