{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:12:57Z","timestamp":1787314377439,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T00:00:00Z","timestamp":1187827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Toll\u2010like receptors (TLRs) regulate dendritic cell function and activate signals that mediate the nature of the adaptive immune response. The current study examined the role of TLRs in dendritic cell activation and in regulating T cell and antibody responses to antigens from the filarial parasites<\/jats:italic>\n                    Onchocerca volvulus\n                    <jats:italic>and<\/jats:italic>\n                    Brugia malayi\n                    <jats:italic>, which cause river blindness and lymphatic filariasis, respectively. Bone\u2010marrow\u2010derived CD11c<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    <jats:italic>cells from C57BL\/6 and TLR4<\/jats:italic>\n                    <jats:sup>\u2212\/\u2013<\/jats:sup>\n                    <jats:italic>mice produced high levels of IL\u20106 and RANTES, and showed elevated surface CD40 expression, whereas CD11c<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    <jats:italic>cells from myeloid differentiation factor 88<\/jats:italic>\n                    <jats:sup>\u2212\/\u2013<\/jats:sup>\n                    <jats:italic>(MyD88<\/jats:italic>\n                    <jats:sup>\u2212\/\u2013<\/jats:sup>\n                    <jats:italic>), TLR2<\/jats:italic>\n                    <jats:sup>\u2212\/\u2013<\/jats:sup>\n                    <jats:italic>and TLR2\/4<\/jats:italic>\n                    <jats:sup>\u2212\/\u2013<\/jats:sup>\n                    <jats:italic>mice were not activated. Similarly, IFN\u2010\u03b3 production by splenocytes from immunized TLR2<\/jats:italic>\n                    <jats:sup>\u2212\/\u2013<\/jats:sup>\n                    <jats:italic>mice was significantly impaired compared with splenocytes from C57BL\/6 and TLR4<\/jats:italic>\n                    <jats:sup>\u2212\/\u2013<\/jats:sup>\n                    <jats:italic>mice. In contrast, there was no difference among these strains in Th2\u2010associated responses including IL\u20105 production by splenocytes from immunized animals, serum IgE and IgG<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    <jats:italic>, or eosinophil infiltration into the corneal stroma. Neutrophil recruitment to the cornea and<\/jats:italic>\n                    <jats:italic>CXC chemokine production was inhibited in immunized TLR2<\/jats:italic>\n                    <jats:sup>\u2212\/\u2013<\/jats:sup>\n                    <jats:italic>mice compared with C57BL\/6 and TLR4<\/jats:italic>\n                    <jats:sup>\u2212\/\u2013<\/jats:sup>\n                    <jats:italic>mice. Taken together, these findings demonstrate an essential role for TLR2 in filaria\u2010induced dendritic cell activation, IFN\u2010\u03b3 production and neutrophil migration to the cornea, but does not affect filaria\u2010induced Th2\u2010associated responses.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1111\/j.1365-3024.2007.00962.x","type":"journal-article","created":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T07:30:36Z","timestamp":1187854236000},"page":"455-465","source":"Crossref","is-referenced-by-count":22,"title":["Filaria\/\n                    <i>Wolbachia<\/i>\n                    activation of dendritic cells and development of Th1\u2010associated responses is dependent on Toll\u2010like receptor 2 in a mouse model of ocular onchocerciasis (river blindness)"],"prefix":"10.1111","volume":"29","author":[{"given":"K.","family":"DAEHNEL","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"GILLETTE\u2010FERGUSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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