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For this purpose, an international workshop provided a platform for the classification of <\/jats:italic>T. spiralis<jats:italic> antigens. ML antigens were classified in eight groups \u2013<\/jats:italic>Trichinella spiralis<jats:italic> larvae groups, TSL\u20101 to TSL\u20108. TSL\u20101 antigens are highly immunogenic and a number of important studies have been performed to analyse the role of these antigens in the host\u2013parasite interplay.<\/jats:italic><\/jats:p><jats:p> <jats:italic>In this context, we have focused on the analysis of the role of TSL\u20101 antigens in the induction of innate immune responses with particular emphasis on the activation of mast cells (MC) by an IgE\u2010independent pathway. These studies provided evidence on the role of mediator release from TSL\u20101\u2010activated MC in the development of Type 2 immune responses. The protective role of TSL\u20101 in <\/jats:italic>T. spiralis<jats:italic>\u2010infected mice has been described. In addition, it has been demonstrated that the use of TSL\u20101 antigens allows for a more sensitive and specific diagnosis of human and animal trichinellosis.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1365-3024.2007.00985.x","type":"journal-article","created":{"date-parts":[[2007,12,4]],"date-time":"2007-12-04T00:23:03Z","timestamp":1196727783000},"page":"661-670","source":"Crossref","is-referenced-by-count":22,"title":["Contributions to the study of <i>Trichinella spiralis<\/i> TSL\u20101 antigens in host 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