{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:57:08Z","timestamp":1791262628652,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,1,3]],"date-time":"2008-01-03T00:00:00Z","timestamp":1199318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p> <jats:italic>Infection with <\/jats:italic>Cryptosporidium <jats:italic>spp. causes diarrhoeal disease and has become an important medical and veterinary problem especially in the immunocompromised host. The importance of the adaptive immune response, with CD4<jats:sup>+<\/jats:sup>\u00a0T\u2010lymphocytes being the major players, has been clearly demonstrated. The requirement of IL\u201012 and IFN\u2010\u03b3 identifies this response as a Th1\u2010dominated reaction. IFN\u2010\u03b3 is also important in the early phase of the host\u2013parasite interaction. We analysed the outcome of infection in IL\u201012p40 (IL\u201012KO) and IFN\u2010\u03b3 (GKO) deficient C57BL\/6 mice after primary and secondary challenge with the parasite and, for the first time, we demonstrate the resulting Ig response in sera and vaginal lavages. Although showing differences in the extent and the time course both strains of mice were able to clear infection and developed an almost complete resistance to re\u2010infection. While GKO mice mounted prolonged parasite\u2010specific IgG and IgA responses after primary infection, in IL\u201012KO mice IgG and IgA titres dropped over time. Re\u2010challenge of mice 5 weeks after primary infection led to a booster effect in Ig response despite the absence of oocyst shedding. The data from infection and re\u2010challenge experiments suggest that in IL\u201012\u2010 or IFN\u2010\u03b3\u2010deficient mice the development of resistance involves other protective immune responses.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1365-3024.2007.01013.x","type":"journal-article","created":{"date-parts":[[2008,1,30]],"date-time":"2008-01-30T15:22:36Z","timestamp":1201706556000},"page":"151-161","source":"Crossref","is-referenced-by-count":34,"title":["Humoral immune response in IL\u201012 and IFN\u2010\u03b3 deficient mice after infection with <i>Cryptosporidium parvum<\/i>"],"prefix":"10.1111","volume":"30","author":[{"given":"V.","family":"JAKOBI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"PETRY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000060371"},{"key":"e_1_2_6_3_2","first-page":"100S","article-title":"Cryptosporidium infections in inbred strains of mice","volume":"38","author":"Enriquez FJ","year":"1991","journal-title":"J Protozool"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1128\/iai.38.2.471-475.1982","article-title":"Experimental cryptosporidiosis in laboratory mice","volume":"38","author":"Sherwood D","year":"1982","journal-title":"Infect Immun"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1128\/iai.58.4.961-969.1990","article-title":"New mouse models for chronic Cryptosporidium infection in immunodeficient hosts","volume":"58","author":"Ungar BL","year":"1990","journal-title":"Infect Immun"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1128\/iai.43.3.856-859.1984","article-title":"Persistent Cryptosporidium infection in congenitally athymic (nude) mice","volume":"43","author":"Heine J","year":"1984","journal-title":"Infect Immun"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/163.6.1297"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1128\/iai.61.9.3928-3932.1993","article-title":"Requirements for CD4+ cells and \u03b3\u2010interferon in resolution of established Cryptosporidium parvum infection in mice","volume":"61","author":"Chen W","year":"1993","journal-title":"Infect Immun"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.4049\/jimmunol.147.3.1014","article-title":"Cryptosporidium infection in an adult mouse model. 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