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Child anthelminthic treatment programmes are being implemented but repeated treatments are costly, may prevent the development of acquired immunity and can lead to the development of drug resistant parasites. Thus, the development of a vaccine which would lead to the acquisition of immunity at an earlier age and reduce community faecal egg output would be beneficial. Development of subunit vaccines requires the identification of protective antigens and their formulation in a suitable adjuvant. <\/jats:italic>Trichuris muris <jats:italic>is an antigenically similar laboratory model for <\/jats:italic>T. trichiura.<jats:italic> Subcutaneous vaccination with adult excretory\u2013secretory products (ES) protects susceptible mouse strains from <\/jats:italic>T. muris<jats:italic>. Larval stages may contain novel and more relevant antigens which when incorporated in a vaccine induce worm expulsion earlier in infection than the adult worm products. This study finds <\/jats:italic>negligible<jats:italic> difference in the cellular and humoral immune response to <\/jats:italic>T. muris<jats:italic> adult and third stage larva(e) (L3) ES <\/jats:italic>during a primary T. muris infection<jats:italic>, but identifies high molecular weight proteins in both adult and L3 ES as potential vaccine candidates.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1365-3024.2008.01035.x","type":"journal-article","created":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T08:06:32Z","timestamp":1208333192000},"page":"454-461","source":"Crossref","is-referenced-by-count":17,"title":["Antigen selection for future anti\u2010<i>Trichuris<\/i> vaccines: a comparison of cytokine and antibody responses to larval and adult antigen in a primary infection"],"prefix":"10.1111","volume":"30","author":[{"given":"H.","family":"DIXON","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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