{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:14:38Z","timestamp":1757704478613},"reference-count":44,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2008,8,4]],"date-time":"2008-08-04T00:00:00Z","timestamp":1217808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p> <jats:italic>Cercariae of bird schistosomes (genus <\/jats:italic>Trichobilharzia<jats:italic>) are able to penetrate the skin of mammals (noncompatible hosts), including humans, and cause a Th2\u2010associated inflammatory cutaneous reaction termed cercarial dermatitis. The present study measured the antibody reactivity and antigen specificity of sera obtained after experimental infection of mice and natural infection of humans. Sera from mice re\u2010infected with <\/jats:italic>T. regenti<jats:italic> showed a bias towards the development of antigen\u2010specific IgM and IgG1 antibodies and elevated levels of total serum IgE, indicative of a Th2 polarized immune response. We also demonstrate that cercariae are a source of antigens triggering IL\u20104 release from basophils collected from healthy human volunteers. Analysis of sera from patients with a history of cercarial dermatitis revealed elevated levels of cercarial\u2010specific IgG, particularly for samples collected from adults (&gt;\u00a014\u00a0years old) comparedwith children (8\u201314\u00a0years old), although elevated levels of antigen\u2010specific IgE were not detected. In terms of antigen recognition, IgG and IgE antibodies in the sera of both mice and humans preferentially bound an antigen of 34\u00a0kDa. The 34\u00a0kDa molecule was present in both homogenate of cercariae, as well as cercarial excretory\/secretory products, and we speculate it may represent a major immunogen initiating the Th2\u2010immune response associated with cercarial dermatitis.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1365-3024.2008.01059.x","type":"journal-article","created":{"date-parts":[[2008,8,4]],"date-time":"2008-08-04T09:54:23Z","timestamp":1217843663000},"page":"585-595","source":"Crossref","is-referenced-by-count":18,"title":["Antibody responses induced by <i>Trichobilharzia regenti<\/i> antigens in murine and human hosts exhibiting cercarial dermatitis"],"prefix":"10.1111","volume":"30","author":[{"given":"L.","family":"LICHTENBERGOV\u00c1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"KOLBEKOV\u00c1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"KOU\u0158ILOV\u00c1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"KA\u0160N\u00dd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"MIKE\u0160","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"HAAS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"SCHRAMM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"HOR\u00c1K","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"KOL\u00c1\u0158OV\u00c1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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