{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:48:30Z","timestamp":1789573710347,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,5,9]],"date-time":"2011-05-09T00:00:00Z","timestamp":1304899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The knowledge on immune mechanisms of chronic urticaria (CU) at the cytokine level is widely scarce. We compared pro\u2010 and anti\u2010inflammatory as well as Th1\u2010 and Th2\u2010associated serum cytokine levels in two phenotypes of CU: associated with (CU+) and without (CU\u2212) sensitization against <jats:italic>Anisakis simplex<\/jats:italic>, a ubiquitous fish parasite, that has been associated with acute urticaria in gastro\u2010allergic anisakiasis (GAA) and with CU+. Thirteen CU+ and 19 CU\u2212 patients were compared with 13 GAA patients and 15 control subjects for cytokines, measured by cytometric bead array. Urticaria activity score was positively correlated with IL\u20106 in CU\u2212. Serum levels of IL\u201010 were lower in CU+ and CU\u2212 with respect to the control group. Median IFN\u2010\u03b3 was lower in all urticaria groups. Patients with previous parasitism by <jats:italic>A.\u00a0simplex<\/jats:italic> displayed higher TGF\u2010\u03b2 levels than subjects without previous parasitism. The main finding was lower levels of IL\u201017 in CU+ with respect to GAA or controls, with a further tendency to even lower levels in CU\u2212. Different urticaria phenotypes are associated with distinct serum cytokine levels.<\/jats:p>","DOI":"10.1111\/j.1365-3024.2011.01282.x","type":"journal-article","created":{"date-parts":[[2011,2,9]],"date-time":"2011-02-09T11:37:24Z","timestamp":1297251444000},"page":"357-362","source":"Crossref","is-referenced-by-count":25,"title":["Different serum cytokine levels in chronic vs. acute <i>Anisakis simplex<\/i> sensitization\u2010associated urticaria"],"prefix":"10.1111","volume":"33","author":[{"given":"A.","family":"DASCHNER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"RODERO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"DE FRUTOS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"VALLS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"VEGA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"BLANCO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"CU\u00c9LLAR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,9]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.105706"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200410000-00010"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000168795.12701.fd"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1157\/13070606"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-004-1085-9"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02507.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00569.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000066772"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(00)90194-5"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2008.01041.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1069-9"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.05.016"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.06.008"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01036.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2004.07.006"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00296.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000058004"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.06.039"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:26:1:35"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.296.5567.490"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900897"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3024.2011.01282.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3024.2011.01282.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T10:02:15Z","timestamp":1698746535000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3024.2011.01282.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,9]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1111\/j.1365-3024.2011.01282.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3024.2011.01282.x","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,9]]}}}