{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T16:19:35Z","timestamp":1774282775961,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T00:00:00Z","timestamp":1302220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Inflammatory responses to microbial products are amplified by a pathway mediated by triggering a receptor expressed on the myeloid cells (TREM)\u20101. Relatively a few studies have been performed to investigate the role of TREM\u20101 in macrophage activation in response to parasitic infection. In this study, we delineate the role of the innate immunoreceptor TREM\u20101 in the parasite <jats:italic>Schistosoma mansoni<\/jats:italic> infection model from early to late (chronic) phases of infection. Flow cytometry analysis revealed gradual increase in the production of TREM\u20101 protein on CD11b<jats:sup>+<\/jats:sup> myeloid cells, with maximum production at 5\u2003weeks p.i. Similar results in the pattern of TREM\u20101 mRNA expressions in splenic CD11b<jats:sup>+<\/jats:sup> cells from infected mice were obtained by real\u2010time PCR. However, unlike in spleen, the TREM\u20101 mRNA expression in liver tissue showed no significant increase throughout the infection, including periods of maximum production of parasite eggs. Administration of schistosoma egg homogenate antigen to stimulate J774A.1 cells inhibited TREM\u20101 expression on the surface, indicating that some substances of the <jats:italic>Schistosma<\/jats:italic> eggs may inhibit the expression of TREM\u20101 on macrophages, lowering the macrophage\u2010mediated inflammatory response of infected hosts.<\/jats:p>","DOI":"10.1111\/j.1365-3024.2011.01284.x","type":"journal-article","created":{"date-parts":[[2011,2,17]],"date-time":"2011-02-17T15:00:22Z","timestamp":1297954822000},"page":"276-286","source":"Crossref","is-referenced-by-count":14,"title":["Triggering receptor expressed on myeloid cells (TREM)\u20101 participates in <i>Schistosoma mansoni<\/i> inflammatory responses"],"prefix":"10.1111","volume":"33","author":[{"given":"P.\u2010C.","family":"CHENG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010N.","family":"LIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u2010J.","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.\u2010S.","family":"CHANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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