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Analysis of cerebrospinal fluid (CSF) is pivotal for detecting diseases in CNS and, although a specific diagnosis may not be achieved, this analysis is helpful to confirm the diagnosis or to rule out relevant differential diagnoses. This study examined the levels of MMP\u20102 and MMP\u20109 in the CSF of dogs using gelatin zymography to verify possible alterations in these enzymes during natural systemic infection with <jats:italic>Leishmania chagasi<\/jats:italic>. Latent and active forms of MMP\u20102 were detected in some dogs of both groups, with high levels in the control group. In contrast, latent and active forms of MMP\u20109 were detected only in some animals with leishmaniasis. These results clearly demonstrate that MMP\u20109 is elevated in CSF of dogs with visceral leishmaniasis (VL). Although these results are preliminary, they suggest that MMP\u20109 might play a role in disruption of blood\u2013brain barrier and\/or blood\u2013CSF barrier. While the presence of MMPs in CSF is not a condition exclusive to VL, their presence and persistence in CSF supports the hypothesis of an inflammatory state within CNS of dogs with VL.<\/jats:p>","DOI":"10.1111\/j.1365-3024.2011.01285.x","type":"journal-article","created":{"date-parts":[[2011,2,19]],"date-time":"2011-02-19T14:20:34Z","timestamp":1298125234000},"page":"330-334","source":"Crossref","is-referenced-by-count":24,"title":["Levels of matrix metalloproteinase\u20102 and metalloproteinase\u20109 in the cerebrospinal fluid of dogs with visceral leishmaniasis"],"prefix":"10.1111","volume":"33","author":[{"given":"N. R.","family":"MARANGONI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. D.","family":"MELO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. 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