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The participation of <jats:italic>O<\/jats:italic>\u2010GlcNAc moieties in the molecular antigenicity of Cz was determined using GlcNAc linked to aprotinin by ELISA. The immune cross\u2010reactivity between Cz and myosin is mainly focused in the C\u2010T domain. ELISA inhibition assays using rabbit sera specific for Cz and C\u2010T in conjunction with immune\u2010gold electron microscopy analysis of heart tissues from mice immunized with C\u2010T confronted with polyclonal rabbit sera specific for Cz and C\u2010T prior and after myosin adsorption provided evidence which indicates that O\u2010GlcNAc moieties constitute a common epitope between Cz and either myosin or other cardiac O\u2010GlcNAc\u2010containing proteins, showing a new insight into the molecular immune pathogenesis of Chagas heart disease.<\/jats:p>","DOI":"10.1111\/j.1365-3024.2011.01291.x","type":"journal-article","created":{"date-parts":[[2011,3,23]],"date-time":"2011-03-23T08:19:40Z","timestamp":1300868380000},"page":"363-370","source":"Crossref","is-referenced-by-count":13,"title":["A striking common <i>O<\/i>\u2010linked <i>N<\/i>\u2010acetylglucosaminyl moiety between cruzipain and myosin"],"prefix":"10.1111","volume":"33","author":[{"given":"D. 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