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The ImmunoCAP system revealed very high specificity (one false positive of 110 healthy individuals), low cross\u2010reactivity (one false positive of 58 patients with other diseases) and decreased sensitivity (73\u00b755%). Receiver operating characteristic analysis displayed a beneficial diagnostic value with high accuracy. Comparison of the ImmunoCAP system with ELISA and Western blot showed significantly higher specificity and significantly lower cross\u2010reactivity compared with the ELISA. Examination of sera from 155 patients with cystic echinococcosis (CE) showed varying levels of anti\u2010<jats:italic>Echinococcus<\/jats:italic> IgE (range, 0\u00b701\u2013118\u00b733\u2003kUA\/L). However, most samples had moderately elevated IgE levels. Analysis of serum\u2010specific IgE revealed significantly higher sensitivity of the ImmunoCAP system and significantly higher antibody levels in hepatic CE compared with pulmonary CE.<\/jats:p>","DOI":"10.1111\/j.1365-3024.2011.01292.x","type":"journal-article","created":{"date-parts":[[2011,4,11]],"date-time":"2011-04-11T12:43:07Z","timestamp":1302525787000},"page":"371-376","source":"Crossref","is-referenced-by-count":10,"title":["Quantitative assessment of serum\u2010specific IgE in the diagnosis of human cystic echinococcosis"],"prefix":"10.1111","volume":"33","author":[{"given":"I.","family":"MARINOVA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"NIKOLOV","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"MICHOVA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"KURDOVA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"PETRUNOV","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01569.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01807.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-004-0004-2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(86)90378-7"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1992.tb00683.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115606"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2006.00837.x"},{"key":"e_1_2_6_9_2","first-page":"813","article-title":"Quantitative determination of specific IgE antibodies to Echinococcus granulosus and IgE levels in sera from patients with hydatid disease","volume":"29","author":"Dessaint JP","year":"1975","journal-title":"Immunology"},{"key":"e_1_2_6_10_2","unstructured":"FDA\/CDRH.Radioallergosorbent test (RAST) for allergen specific Immunoglobulin E (IgE) 510 (k)s; final guideline for industry and FDA 2001 16."},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.4.3.273"},{"key":"e_1_2_6_12_2","first-page":"133","volume-title":"Medimond International Proceedings of X European multicolloquium of parasitology","author":"Marinova I","year":"2008"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.9.4350"},{"key":"e_1_2_6_15_2","unstructured":"WHO\/OIE Manual on echinococcosis in humans and animals: a public health problem of global concern.EckertJ GemmellMA MeslinF\u2010X&PawlowskiZS(eds): Paris France:World Organization of Animal Health 2002: 265."},{"key":"e_1_2_6_16_2","first-page":"587","article-title":"Detection of specific IgE antibodies in sera from patients with hydatidosis","volume":"55","author":"Afferni C","year":"1984","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000234656"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/15.3.473"},{"key":"e_1_2_6_19_2","first-page":"119","article-title":"Reacciones de hypersensibilidad immediata en la hydatidosis humana. 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