{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:27:53Z","timestamp":1762079273087},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,6,15]],"date-time":"2011-06-15T00:00:00Z","timestamp":1308096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Alternatively activated macrophages (AAMs) have key roles in the immune response to a variety of gastrointestinal helminths such as <jats:italic>Heligmosomoides bakeri<\/jats:italic> and <jats:italic>Nippostrongylus brasiliensis<\/jats:italic>. In addition, AAMs have been implicated in the resolution of infection\u2010induced pathology in <jats:italic>Schistosoma mansoni<\/jats:italic> infection. AAMs exert their activity in part via the enzyme arginase\u20101 (Arg1), which hydrolyses <jats:sc>l<\/jats:sc>\u2010arginine into urea and ornithine, and can supply precursor substrate for proline and polyamine production. <jats:italic>Trichuris muris<\/jats:italic> is a worm that resides in the large intestine with resistance being characterized by a Th2 T\u2010cell response, which drives alternatively activated macrophage production in the local environment of the infection. To investigate the role of AAMs in <jats:italic>T.\u00a0muris<\/jats:italic> infection, we used independent genetic and pharmacologic models of arginase deficiency. In acute infection and Th2\u2010dominated immunity, arginase\u2010deficient models expelled worms normally. Macrophage\u2010Arg1\u2010deficient mice showed cytokine and antibody levels comparable to wild\u2010type animals in acute and chronic infection. We also found no role for AAMs and Arg1 in infection\u2010induced pathology in the response to <jats:italic>T.\u00a0muris<\/jats:italic> in either chronic (Th1 dominated) or acute (Th2 dominated) infections. Our data demonstrate that, unlike other gastrointestinal helminths, Arg1 expression in AAMs is not essential for resistance to <jats:italic>T.\u00a0muris<\/jats:italic> in effective resolution of helminth\u2010induced inflammation.<\/jats:p>","DOI":"10.1111\/j.1365-3024.2011.01300.x","type":"journal-article","created":{"date-parts":[[2011,5,18]],"date-time":"2011-05-18T05:51:20Z","timestamp":1305697880000},"page":"411-420","source":"Crossref","is-referenced-by-count":36,"title":["Arginase\u20101\u2010expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth <i>Trichuris muris<\/i>"],"prefix":"10.1111","volume":"33","author":[{"given":"R.","family":"BOWCUTT","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. V.","family":"BELL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"LITTLE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"WILSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"BOOTH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"MURRAY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. J.","family":"ELSE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"CRUICKSHANK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,6,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903356"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0602325"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.09.012"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2007.07.002"},{"key":"e_1_2_6_6_2","first-page":"255","volume-title":"Advances in Parasitology","author":"Cliffe LJ","year":"2004"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.077"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2007.00973.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1451"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000371"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3416fje"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.0106"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1671"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000072395"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1990.tb00985.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000079762"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/pim.1993.15.10.595"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.10.6713"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1108661"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00107-4"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902009"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000480"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.7.3655"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802767"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3024.2011.01300.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3024.2011.01300.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T10:20:34Z","timestamp":1698747634000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3024.2011.01300.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,15]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1111\/j.1365-3024.2011.01300.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3024.2011.01300.x","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,15]]}}}