{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:39:40Z","timestamp":1791196780349,"version":"4.1.0"},"reference-count":96,"publisher":"Wiley","issue":"2-3","license":[{"start":{"date-parts":[[2012,2,11]],"date-time":"2012-02-11T00:00:00Z","timestamp":1328918400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We describe recent advances in the genomics and population biology of <jats:italic>Cryptosporidium parvum<\/jats:italic> and <jats:italic>C. hominis<\/jats:italic>, the causative agents of cryptosporidiosis in humans and animals. Many basic aspects of the biology of <jats:italic>Cryptosporidium<\/jats:italic> species remain to be investigated and effective drugs to control cryptosporidiosis are not available. Sequencing and annotation of the genome of <jats:italic>C. parvum<\/jats:italic> and <jats:italic>C. hominis<\/jats:italic> has uncovered unique features of the metabolism of these species. The recently sequenced genome of the gastric species <jats:italic>C. muris<\/jats:italic> is providing new insights into the evolution of the genus. Cryptosporidian sequence information has facilitated the identification of polymorphic genetic markers. Genotyping of oocysts excreted by human and animal hosts using such markers has revealed many new species and genotypes, and is leading to a better understanding of the epidemiology of cryptosporidiosis.<\/jats:p>","DOI":"10.1111\/j.1365-3024.2011.01301.x","type":"journal-article","created":{"date-parts":[[2011,5,19]],"date-time":"2011-05-19T15:44:22Z","timestamp":1305819862000},"page":"61-71","source":"Crossref","is-referenced-by-count":73,"title":["Genomics and population biology of <i>Cryptosporidium<\/i> species"],"prefix":"10.1111","volume":"34","author":[{"given":"G.","family":"WIDMER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"SULLIVAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.8.3960-3969.1999"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80503-3"},{"key":"e_1_2_6_4_2","first-page":"228","article-title":"Pathological and microbiological observations made on spontaneous cases of acute neonatal calf diarrhea","volume":"40","author":"Morin M","year":"1976","journal-title":"Can J Comp Med"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/147.5.824"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198305263082102"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(99)00225-X"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1996.11813090"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0304686101"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199407213310304"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.09.072512"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.2004.tb00291.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60117-7"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1992.tb12370.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2003.68.710"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.2002.tb00224.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1101\/gr.1555203","article-title":"Integrated mapping, chromosomal sequencing and sequence analysis of Cryptosporidium parvum","volume":"13","author":"Bankier AT","year":"2003","journal-title":"Genome Res"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2006.75.851"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.112.6.116"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(92)90165-9"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1128\/cdli.1.4.450-463.1994","article-title":"Evaluation of an animal model system for cryptosporidiosis: therapeutic efficacy of paromomycin and hyperimmune bovine colostrum\u2010immunoglobulin","volume":"1","author":"Tzipori S","year":"1994","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh050"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094786"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02977"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2005.02.002"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003335107"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(91)90227-W"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1937-6448(10)81005-6"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2004-5-11-r88"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msp226"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.2006.00229.x"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.2005.04-3317.x"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2010.04.005"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2008.07.004"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2008.12.014"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.2615304"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200900323"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00536023"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2006.08.001"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004360050655"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.02284-0"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1645\/GE-1028R1.1"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2010.05.010"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00931827"},{"key":"e_1_2_6_45_2","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1128\/aem.62.2.712-716.1996","article-title":"Identification of genetic heterogeneity in the Cryptosporidium parvum ribosomal repeat","volume":"62","author":"Carraway M","year":"1996","journal-title":"Appl Environ Microbiol"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0304.970423"},{"key":"e_1_2_6_47_2","first-page":"46S","article-title":"Microsatellite analysis of the human and bovine genotypes of Cryptosporidium parvum","volume":"46","author":"Aiello AE","year":"1999","journal-title":"J Eukaryot Microbiol"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.66.8.3344-3349.2000"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182099005508"},{"key":"e_1_2_6_50_2","first-page":"331","article-title":"Ultrastructure of microgametogenesis, microgametes and gametogamy of Cryptosporidium sp. in the small\u2010intestine of mice","volume":"18","author":"Goebel E","year":"1982","journal-title":"Protistologica"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60353-X"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1986.tb05608.x"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(01)00393-0"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-002-2412-3"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-1348(03)00089-3"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.7.4117-4134.2000"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01268-10"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.2307\/3281435"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1007.030582"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.70.7.3973-3978.2004"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268805004772"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0901.020512"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503303321304"},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.7.3881-3890.2002"},{"key":"e_1_2_6_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-006-0164-5"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1410.071273"},{"key":"e_1_2_6_67_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182009991089"},{"key":"e_1_2_6_68_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268808000769"},{"key":"e_1_2_6_69_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.156.22.710"},{"key":"e_1_2_6_70_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.9.4992-4997.2005"},{"key":"e_1_2_6_71_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.164.1.24"},{"key":"e_1_2_6_72_2","doi-asserted-by":"publisher","DOI":"10.1645\/0022-3395(2000)086[1352:DOTCPH]2.0.CO;2"},{"key":"e_1_2_6_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(03)00138-5"},{"key":"e_1_2_6_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2009.07.003"},{"key":"e_1_2_6_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2009.03.018"},{"key":"e_1_2_6_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2009.08.003"},{"key":"e_1_2_6_77_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01576-08"},{"key":"e_1_2_6_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a026247"},{"key":"e_1_2_6_79_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.5.1518-1530.2004"},{"key":"e_1_2_6_80_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.7.4108-4116.2000"},{"key":"e_1_2_6_81_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1405.071277"},{"key":"e_1_2_6_82_2","doi-asserted-by":"publisher","DOI":"10.1086\/519842"},{"key":"e_1_2_6_83_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.028001-0"},{"key":"e_1_2_6_84_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02509-09"},{"key":"e_1_2_6_85_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200700804"},{"key":"e_1_2_6_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1226"},{"key":"e_1_2_6_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2003.10.001"},{"key":"e_1_2_6_88_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01009-09"},{"key":"e_1_2_6_89_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-8286.2005.01155.x"},{"key":"e_1_2_6_90_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.6.2805-2809.2005"},{"key":"e_1_2_6_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(01)00233-8"},{"key":"e_1_2_6_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2006.08.006"},{"key":"e_1_2_6_93_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.2006.00169.x"},{"key":"e_1_2_6_94_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.2006.00166.x"},{"key":"e_1_2_6_95_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.72.4.2507-2513.2006"},{"key":"e_1_2_6_96_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1301.060481"},{"key":"e_1_2_6_97_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02536-06"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3024.2011.01301.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3024.2011.01301.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T05:08:55Z","timestamp":1693372135000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3024.2011.01301.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":96,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1111\/j.1365-3024.2011.01301.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3024.2011.01301.x","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}