{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:28:38Z","timestamp":1791044918631,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T00:00:00Z","timestamp":1313020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Intraperitoneal larval infection (alveolar echinococcosis, AE) with Echinococcus multilocularis in mice impairs host immunity. Metacestode metabolites may modulate immunity putatively via dendritic cells. During murine AE, a relative increase of peritoneal DCs (pe\u2010DCs) in infected mice (AE\u2010pe\u2010DCs; 4% of total peritoneal cells) as compared to control mice (na\u00efve pe\u2010DCs; 2%) became apparent in our study. The differentiation of AE\u2010pe\u2010DCs into TGF\u2010\u03b2\u2010expressing cells and the higher level of IL\u20104 than IFN\u2010\u03b3\/IL\u20102 mRNA expression in AE\u2010CD4+pe\u2010T cells indicated a Th2 orientation. Analysis of major accessory molecule expression on pe\u2010DCs from AE\u2010infected mice revealed that CD80 and CD86 were down\u2010regulated on AE\u2010pe\u2010DCs, while ICAM\u20101(CD54) remained practically unchanged. Moreover, AE\u2010pe\u2010DCs had a weaker surface expression of MHC class II (Ia) molecules as compared to na\u00efve pe\u2010DCs. The gene expression level of molecules involved in MHC class II (Ia) synthesis and formation of MHC class II (Ia)\u2013peptide complexes were down\u2010regulated. In addition, metacestodes excreted\/secreted (E\/S) or vesicle\u2010fluid (V\/F) antigens were found to alter MHC class II molecule expression on the surface of BMDCs. Finally, conversely to na\u00efve pe\u2010DCs, an increasing number of AE\u2010pe\u2010DCs down\u2010regulated Con A\u2010induced proliferation of na\u00efve CD4+pe\u2010T cells. These findings altogether suggested that TGF\u2010\u03b2\u2010expressing immature AE\u2010pe\u2010DCs might play a significant role in the generation of a regulatory immune response within the peritoneal cavity of AE\u2010infected mice.<\/jats:p>","DOI":"10.1111\/j.1365-3024.2011.01303.x","type":"journal-article","created":{"date-parts":[[2011,5,25]],"date-time":"2011-05-25T10:53:32Z","timestamp":1306320812000},"page":"471-482","source":"Crossref","is-referenced-by-count":28,"title":["Intraperitoneal murine <i>Echinococcus multilocularis<\/i> infection induces differentiation of TGF\u2010\u03b2\u2010expressing DCs that remain immature"],"prefix":"10.1111","volume":"33","author":[{"given":"N.","family":"MEJRI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"M\u00dcLLER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"GOTTSTEIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2008.03.002"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1385\/IR:29:1-3:187"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021908"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141126"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(99)80066-1"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0503226"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.12.6453"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.1982"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.5837"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.4.1704"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(03)00072-4"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00191.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2001.00374.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/9.6.889"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60024-X"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00932028"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1998.0426"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.3.1569-1573.2003"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13360"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(98)00204-X"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)69848-0"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(84)90782-6"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00901.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2010.10.002"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/32588"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1005547"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2009.02.003"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1159\/000088881"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(01)02012-9"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00144.x"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(02)00343-6"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1001"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/365797a0"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.145.11.3796"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/383787a0"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80533-6"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.2307\/3283349"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830260528"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0141-9838.2004.00724.x"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1999.276.5.G1074"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.163.5.1037"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.1.121"},{"key":"e_1_2_6_44_2","doi-asserted-by":"crossref","first-page":"6461","DOI":"10.1128\/IAI.67.12.6461-6472.1999","article-title":"Regulation of human CD4(+) alpha\u2010beta T\u2010cell\u2010receptor\u2010positive (TCR(+)) and gamma\u2010delta TCR(+) T\u2010cell responses to Mycobacterium tuberculosis by interleukin\u201010 and transforming growth factor beta","volume":"67","author":"Rojas RE","year":"1999","journal-title":"Infect Immun"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.2.379"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2132"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.11.008"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(11)80550-4"},{"key":"e_1_2_6_49_2","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.4049\/jimmunol.158.3.1095","article-title":"TGF\u2010beta attenuates the class II transactivator and reveals an accessory pathway of IFN\u2010gamma action","volume":"158","author":"Nandan D","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/10.11.1713"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1158"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80249-6"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.5.1729"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.2.245"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.6.2153"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81030-2"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3024.2011.01303.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3024.2011.01303.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T21:27:02Z","timestamp":1698787622000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3024.2011.01303.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,11]]},"references-count":55,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1111\/j.1365-3024.2011.01303.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3024.2011.01303.x","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,11]]}}}