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Epidemiological observations have suggested that the clinical evolution of <jats:italic>P.\u00a0falciparum<\/jats:italic> infections may be influenced by the concurrent presence of another <jats:italic>Plasmodium<\/jats:italic> species. Infection of susceptible mouse strains with <jats:italic>P.\u00a0berghei<\/jats:italic> ANKA (PbA) provides an experimental model of cerebral malaria which has been extensively used to identify different components of the immune system involved in cerebral malaria. This model has also been employed to investigate the influence of experimental mixed\u2010<jats:italic>Plasmodium<\/jats:italic>\u2010species infections on the expression of cerebral malaria; PbA\u2010induced cerebral malaria is completely inhibited by the simultaneous presence of <jats:italic>P.\u00a0yoelii yoelii<\/jats:italic> 17X clone 1.1 parasites, and accumulation of CD8<jats:sup>+<\/jats:sup> T cells in the brain vasculature is abolished. We investigated whether brain levels of CD8<jats:sup>+<\/jats:sup>\u2010T\u2010cell\u2010chemoattractant chemokines CCL3, CCL4 and CCL5 are reduced in these protected coinfected mice compared with PbA\u2010infected mice. Coinfected mice were found to exhibit significantly reduced levels of all three chemokines on day 6 post\u2010infection. This finding may contribute to the abolition of the accumulation of CD8<jats:sup>+<\/jats:sup> T cells in the brain vasculature and the prevention of the development of cerebral malaria in coinfected mice.<\/jats:p>","DOI":"10.1111\/j.1365-3024.2011.01329.x","type":"journal-article","created":{"date-parts":[[2011,8,18]],"date-time":"2011-08-18T19:49:21Z","timestamp":1313696961000},"page":"637-641","source":"Crossref","is-referenced-by-count":16,"title":["Cerebral malaria protection in mice by species\u2010specific <i>Plasmodium<\/i> coinfection is associated with reduced CC chemokine levels in the brain"],"prefix":"10.1111","volume":"33","author":[{"given":"C. J.","family":"CLARK","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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