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By real\u2010time fluorescent quantitative reverse\u2010transcription polymerase chain reaction, we measured the expression level of TLR2 and TLR4 mRNA in peripheral blood mononuclear cells (PBMCs), and using ELISA, we detected the cytokines IFN\u2010\u03b3, IL\u201012p70, IL\u201010, IL\u20104 and IL\u201017A from 34 chronic CE cases (four patients with biliary leakage; four patients with secondary location including three in lung and one in bone) and 22 healthy controls (HC). TLR2 and TLR4 mRNA expression were significantly higher in the CE group (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b705); levels of serum IL\u201010, IL\u20104 and IL\u201012p70 in patients with CE were significantly higher than those in controls (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b705). There were no differences in IFN\u2010\u03b3 and IL\u201017A levels between the CE group and the HC group (<jats:italic>P<\/jats:italic>\u2003&gt;\u20030\u00b705). In the patients with CE, positive correlations were noted between the expression of TLR2 and the serum level of IL\u201010, as well as between the expression of TLR4 and the serum level of IL\u201010. Our findings supported the hypothesis that during chronic CE infection, altered TLR expression might be involved in the cytokine modulation, which allowed the parasite to escape host immunosurveillance and promoted chronic infection.<\/jats:p>","DOI":"10.1111\/j.1365-3024.2011.01335.x","type":"journal-article","created":{"date-parts":[[2011,9,19]],"date-time":"2011-09-19T09:28:29Z","timestamp":1316424509000},"page":"692-696","source":"Crossref","is-referenced-by-count":18,"title":["TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL\u201010"],"prefix":"10.1111","volume":"33","author":[{"given":"J.\u2010Y.","family":"SHAN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.\u2010Z.","family":"JI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010T.","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"TUXUN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.\u2010Y.","family":"LIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"WEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,13]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"332","article-title":"Coordinating office of the National Survey on the important human parasitic diseases. 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