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This study aimed to compare the effects of anti\u2010helminthic treatment on responses directed against the house dust mite <jats:italic>Dermatophagoides pteronyssinus<\/jats:italic> (Derp1) and <jats:italic>Schistosoma haematobium<\/jats:italic> in Zimbabwean populations living in high and low schistosome infection areas. Derp1\u2010 and schistosome\u2010specific IgE and IgG4 antibodies were quantified by ELISA before and 6\u2003weeks after anti\u2010helminthic treatment. Following treatment, there were changes in the immune responses, which varied with place of residence. After allowing for the effects of sex, age and baseline infection intensity, there was no significant treatment effect on the change in anti\u2010schistosome IgE and IgG4 in the high infection area. However, the anti\u2010schistosome IgE\/IgG4 ratio increased significantly, while anti\u2010Derp1 IgE responses decreased as a result of treatment. In the low infection area, treatment resulted in a significant increase in anti\u2010worm IgE levels, but there was no significant treatment effect on anti\u2010schistosome or anti\u2010Derp1 IgE\/IgG4 ratios. Thus, the study shows that the level of schistosome endemicity affects the host responses to schistosome and mite antigens following anti\u2010helminthic treatment.<\/jats:p>","DOI":"10.1111\/j.1365-3024.2012.01363.x","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T23:06:29Z","timestamp":1331939189000},"page":"330-340","source":"Crossref","is-referenced-by-count":9,"title":["<i>Schistosoma haematobium<\/i> infection levels determine the effect of praziquantel treatment on anti\u2010schistosome and anti\u2010mite antibodies"],"prefix":"10.1111","volume":"34","author":[{"given":"N.","family":"RUJENI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"NAUSCH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"MIDZI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"MDULUZA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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