{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T22:29:56Z","timestamp":1772317796640,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T00:00:00Z","timestamp":1339027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>About 225 million malaria cases have been reported worldwide in 2009, and one\u2010third of the world\u2019s population is infected with parasitic helminths. As helminths and <jats:italic>Plasmodium<\/jats:italic> are co\u2010endemic, concurrent infections frequently occur. Helminths have been shown to modulate the host\u2019s immune response; therefore, pre\u2010existing helminth infections may interfere with the efficient immune response to <jats:italic>Plasmodium<\/jats:italic>. To study the interaction between helminths and <jats:italic>Plasmodium,<\/jats:italic> we established a murine model of co\u2010infection using the gastrointestinal nematode <jats:italic>Strongyloides ratti<\/jats:italic> and <jats:italic>Plasmodium yoelii<\/jats:italic>. We show that a pre\u2010existing <jats:italic>Strongyloides<\/jats:italic> infection slightly enhanced peak parasitemia and weight loss in <jats:italic>P.\u00a0yoelii<\/jats:italic>\u2010infected BALB\/c mice, while disease progression was not altered in co\u2010infected C57BL\/6 mice. The <jats:italic>Plasmodium<\/jats:italic>\u2010induced IFN\u2010\u03b3 production and final clearance of <jats:italic>Plasmodium<\/jats:italic> infection were not affected by <jats:italic>S.\u00a0ratti<\/jats:italic> co\u2010infection in both C57BL\/6 and BALB\/c mice. Interestingly, the T helper cell (Th) 2 response induced by <jats:italic>S.\u00a0ratti<\/jats:italic> was significantly suppressed upon <jats:italic>P.\u00a0yoelii<\/jats:italic> co\u2010infection. This suppressed Th2 response, however, was still sufficient to allow expulsion of <jats:italic>S.\u00a0ratti<\/jats:italic> parasitic adults. Taken together, we provide evidence that simultaneous presence of helminth and protist parasites does not interfere with efficient host defence in our co\u2010infection model although changes in Th responses were observed.<\/jats:p>","DOI":"10.1111\/j.1365-3024.2012.01369.x","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T17:01:52Z","timestamp":1336064512000},"page":"388-393","source":"Crossref","is-referenced-by-count":9,"title":["Efficient control of <i>Plasmodium yoelii<\/i> infection in BALB\/c and C57BL\/6 mice with pre\u2010existing <i>Strongyloides ratti<\/i> infection"],"prefix":"10.1111","volume":"34","author":[{"given":"J.","family":"KOLBAUM","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.\u2010L.","family":"ESCHBACH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"STEEG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"JACOBS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"FLEISCHER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"BRELOER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,7]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1179\/136485906X118468"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1645\/0022-3395(2002)088[0055:IHIAAW]2.0.CO;2"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(03)90117-9"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-3-43"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2003.10.009"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.72.702"},{"key":"e_1_2_7_8_2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4269\/ajtmh.2006.75.194","article-title":"Parasitic co\u2010infections: does Ascaris lumbricoides protect against Plasmodium falciparum infection?","volume":"75","author":"Brutus L","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.73.1124"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2000.00284.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2006.00901.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2199"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00191.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2010.01.028"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s430-001-8017-8"},{"key":"e_1_2_7_16_2","volume-title":"Strongyloidiasis a Major Roundworm Infection of Man","author":"Grove DI","year":"1989"},{"key":"e_1_2_7_17_2","volume-title":"Strongyloides spp. (May 23, 2007), Worm\u2010Book","author":"Viney ME"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-006-0013-2"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(81)90031-X"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2010.01199.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2009.03.005"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.7.4415"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1975.11686998"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1311"},{"key":"e_1_2_7_25_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4049\/jimmunol.141.1.241","article-title":"Immunoregulation in murine malaria. Susceptibility of inbred mice to infection with Plasmodium yoelii depends on the dynamic interplay of host and parasite genes","volume":"141","author":"Sayles PC","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.001045"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.04.015"},{"key":"e_1_2_7_28_2","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.1128\/IAI.66.11.5167-5174.1998","article-title":"Altered immune responses in mice with concomitant Schistosoma mansoni and Plasmodium chabaudi infections","volume":"66","author":"Helmby H","year":"1998","journal-title":"Infect Immun"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2008.02.009"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1645\/GE-456R.1"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2009.04.003"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1086\/426871"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939433"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803790"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2009.08.007"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2009.02.001"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2010.01273.x"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3024.2012.01369.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3024.2012.01369.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T21:35:56Z","timestamp":1698701756000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3024.2012.01369.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,7]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1365-3024.2012.01369.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3024.2012.01369.x","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,7]]}}}