{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T21:40:08Z","timestamp":1699652408997},"reference-count":4,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,6,29]],"date-time":"2006-06-29T00:00:00Z","timestamp":1151539200000},"content-version":"vor","delay-in-days":8976,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[1981,12]]},"abstract":"<jats:p>Inoculation of parental strain lymphocytes into the footpads of young F<jats:sub>1<\/jats:sub> hybrid rats induces GVHR, which can be quantitated by estimation of the weight of the popliteal lymph node 7 days later. In a number of strain combinations adult and old F<jats:sub>1<\/jats:sub> animals were also useful for the assay. In some, however, it was observed that aged F<jats:sub>1<\/jats:sub> rats did not support GVHR to the same extent as young did, when one of the parental strains served as donor for the GVHR, but reacted normally if the other parental strain was used. This phenomenon was analysed in serum and cell transfer experiments as well as in vitro in MLC. It was not possible to transfer suppression in vivo, whereas some degree of specific MLC inhibition was observed when serum from old F<jats:sub>1<\/jats:sub> animals undergoing GVHR was assessed. The \u2018old\u2019 pattern of response could be reverted partially by splenectomy and completely by low dose irradiation of the recipient before GVHR.<\/jats:p>","DOI":"10.1111\/j.1365-3083.1981.tb00599.x","type":"journal-article","created":{"date-parts":[[2006,6,30]],"date-time":"2006-06-30T15:51:00Z","timestamp":1151682660000},"page":"585-590","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Age\u2010Dependent Allospecific Change in Susceptibility to Local Lymph Node GVHR in Rats"],"prefix":"10.1111","volume":"14","author":[{"given":"I.","family":"HERON","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.142.1.197"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197009000-00007"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-196809000-00009"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197701000-00013"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3083.1981.tb00599.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3083.1981.tb00599.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T21:24:38Z","timestamp":1699651478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3083.1981.tb00599.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,12]]},"references-count":4,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1981,12]]}},"alternative-id":["10.1111\/j.1365-3083.1981.tb00599.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3083.1981.tb00599.x","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,12]]},"assertion":[{"value":"2006-06-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}