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Appearance of CD8<jats:sup>+<\/jats:sup> T cells with a changed expression of adhesion molecules reflected polyclonal activation and expansion which was demonstrated not to depend on CD4<jats:sup>+<\/jats:sup> T cells or their products. Cell sorting experiments defined virus\u2010specific CTL to be included in this population (LFA\u20101<jats:sup>hi<\/jats:sup>MEL\u201014<jats:sup>lo<\/jats:sup>), but since about 80% of splenic CD8<jats:sup>+<\/jats:sup> T cells have a changed phenotype, extensive bystander activation must take place; this is indicated also by the finding that CD8<jats:sup>+<\/jats:sup>LFA\u2010l<jats:sup>hi<\/jats:sup> cells transiently express several markers of cellular activation, e. g. transferrin receptor, IL\u20102R\u03b1 and \u03b2. Analysis of cells from the cerebrospinal fluid of mice infected intracerebrally showed that virtually all T cells present belonged to the CD8LFA\u2010l<jats:sup>hi<\/jats:sup> subset and, correspondingly, the ligand ICAM\u20101 was found to be up\u2010regulated on endothelial cells in the inflamed meninges. Preincubation of LCMV\u2010primed donor splenocytes with anti\u2010LFA\u20101 markedly inhibited the transfer of virus\u2010specific delayed\u2010type hypersensitivity to naive recipients. Together, these findings indicate that up\u2010regulation of LFA\u20101 expression is a critical factor involved in directing activated CD8<jats:sup>+<\/jats:sup> T cells to sites of viral infection.<\/jats:p>","DOI":"10.1111\/j.1365-3083.1995.tb03633.x","type":"journal-article","created":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T03:52:15Z","timestamp":1151725935000},"page":"110-118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Lymphocytic Choriomeningitis Virus Infection is Associated with Long\u2010Standing Perturbation of LFA\u20101 Expression on CD8<sup>+<\/sup> T Cells"],"prefix":"10.1111","volume":"42","author":[{"given":"E. C.","family":"ANDERSSON","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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