{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:44:58Z","timestamp":1764402298521},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,3,26]],"date-time":"2004-03-26T00:00:00Z","timestamp":1080259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is still no general vaccine for prevention of disease caused by group\u2010B meningococcal strains. Meningococcal lipopolysaccharides (LPSs) have received attention as potential vaccine candidates, but concerns regarding their safety have been raised. Peptide mimics of LPS epitopes may represent safe alternatives to immunization with LPS. The monoclonal antibody (MoAb) 9\u20102\u2010L3,7,9 [<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#b1\">1<\/jats:ext-link>] specific for <jats:italic>Neisseria meningitidis<\/jats:italic> LPS immunotype L3,7,9 is bactericidal and does not cross\u2010react with human tissue. To explore the possibility of isolating peptide mimics of the epitope recognized by MoAb 9\u20102\u2010L3,7,9, we have constructed two phage display libraries of six and nine random amino acids flanked by cysteines. Furthermore, we developed a system for the easy exchange of peptide\u2010encoding sequences from the phage\u2010display system to a hepatitis B core (HBc) expression system. Cyclic peptides that specifically bound MoAb 9\u20102\u2010L3,7,9 at a site overlapping with the LPS\u2010binding site were selected from both libraries. Three out of four tested peptides which reacted with MoAb 9\u20102\u2010L3,7,9 were successfully presented as fusions to the immunodominant loop of HBc particles expressed in <jats:italic>Escherichia coli<\/jats:italic>. However, both peptide conjugates to keyhole limpet haemocyanin and HBc particle fusions failed to give an anti\u2010LPS response in mice.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2004.01400.x","type":"journal-article","created":{"date-parts":[[2004,3,26]],"date-time":"2004-03-26T16:14:53Z","timestamp":1080317693000},"page":"373-384","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Selection and Characterization of Cyclic Peptides that Bind to a Monoclonal Antibody Against Meningococcal L3,7,9 lipopolysaccharides"],"prefix":"10.1111","volume":"59","author":[{"given":"V.","family":"Lauvrak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Berntzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Heggelund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. K.","family":"Herstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. H.","family":"Sandin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Dalseg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Rosenqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Sandlie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. E.","family":"Michaelsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,3,26]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.40.1.257-264.1983"},{"key":"e_1_2_5_3_2","unstructured":"World Health Report.World health oragnisation2000."},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08416-7"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00410-8"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/126.5.514"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90340-9"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6215(83)84020-8"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0882-4010(92)90022-G"},{"key":"e_1_2_5_10_2","first-page":"67","article-title":"Production, characterization and control of MenB\u2010vaccine \u2018Folkehelsa\u2019: an outer membrane vesicle vaccine against group B meningococcal disease","volume":"14","author":"Fredriksen JH","year":"1991","journal-title":"NIPH Ann"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(91)90338-Y"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)85220-1"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/153685902317401690"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568005014605964"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-7012(01)00290-1"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2000.tb09317.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.2.623"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00397-2"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000150481"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(08)60808-8"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.5.1915"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(88)90364-2"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.64.7.3319-3330.1990"},{"key":"e_1_2_5_24_2","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1128\/cdli.1.6.729-736.1994","article-title":"Development, characterization, and biological properties of meningococcal immunotype L3,7 (8),9\u2013specific monoclonal antibodies","volume":"1","author":"Verheul AF","year":"1994","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_5_25_2","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1128\/CDLI.6.6.838-843.1999","article-title":"Comparative analysis of two meningococcal immunotyping monoclonal antibodies by resonant mirror biosensor and antibody gene sequencing","volume":"6","author":"Charalambous BM","year":"1999","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80419-7"},{"key":"e_1_2_5_27_2","doi-asserted-by":"crossref","unstructured":"MichaelsenTE Kolberg J Aase Aet al.The four mouse IgG isotypes differ extensively in bactericidal and opsonophagocytic activity when reacting with the P1.16 epitope on the outer membrane PorA protein ofNeisseria meningitidis.Scand J Immunol2004;59:34\u20139.","DOI":"10.1111\/j.0300-9475.2004.01362.x"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1696028"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-7012(95)00105-0"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(93)17065-D"},{"key":"e_1_2_5_31_2","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.1128\/iai.63.12.4642-4652.1995","article-title":"Human antibody responses to meningococcal outer membrane antigens after three doses of the Norwegian group B meningococcal vaccine","volume":"63","author":"Rosenqvist E","year":"1995","journal-title":"Infect Immun"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.16.e76"},{"key":"e_1_2_5_33_2","unstructured":"DalsegR.Expression of hepatitis B core antigen inE. coli its characterization and properties as carrier of foreign antigenic determinants. [Inaugural\u2010dissertation zur Erlangung der Doktorwurde]. Heidelberg:Ruprecht Karls Universitat 1990."},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200387200"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1996.0438"},{"key":"e_1_2_5_36_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.4049\/jimmunol.160.1.293","article-title":"Peptides that mimic the group B streptococcal type III capsular polysaccharide antigen","volume":"160","author":"Pincus SH","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830271022"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1999.tb01392.x"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M909121199"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5456.1279"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.12.6992"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1006\/biol.2001.0307"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2003.09.015"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3083.2004.01400.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3083.2004.01400.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T04:34:52Z","timestamp":1696912492000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3083.2004.01400.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,26]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1111\/j.1365-3083.2004.01400.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3083.2004.01400.x","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3,26]]},"assertion":[{"value":"2004-03-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}