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A water extract of AbM or PBS control was administered orally before or with challenge to NIH\/OlaHsd mice, experimentally infected intraperitoneally with the moderately virulent <jats:italic>Streptococcus pneumoniae<\/jats:italic> serotype 6B. End points were bacteraemia and survival rate. The AbM extract, protected against systemic <jats:italic>S. pneumoniae<\/jats:italic> 6B infection in the mice. It was most effective when given 24\u2003h before inoculation but did also have protective effects when given together with challenge compared with control. The lack of antibiotic effect on pneumococci <jats:italic>in vitro<\/jats:italic> and increased levels of cytokines MIP\u20102 and TNF\u2010\u03b1 in the serum of mice receiving AbM extract, indicated that the protective effect of AbM was due to the involvement of the native immune system. This is the first report of anti\u2010infection effects of AbM <jats:italic>in vivo<\/jats:italic>. 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