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Meningococcal capsular polysaccharide\u2010based vaccines are effective against the major invasive serogroups, except for serogroup B, the capsule of which mimics human polysaccharides and is poorly immunogenic. An alternative vaccine candidate that has the potential to offer cross\u2010protection against antigenically diverse meningococci is the lipooligosaccharide (LOS). The structurally constrained peptide mimetic, C22, of a bactericidal antibody epitope within LOS was previously shown to elicit cross\u2010reactive antibodies to meningococcal LOS when complexed to NeutrAvidin\u2122 as a carrier protein. The immunogenicity of this antigen in H\u20102<jats:sup>d<\/jats:sup> (BALB\/<jats:italic>c<\/jats:italic>) and H\u20102<jats:sup>k<\/jats:sup> (C3H\/HeN) haplotype mice was further investigated. Anti\u2010LOS immunoglobulin G (IgG) antibody titres increased with the vaccine dose and correlated with the anti\u2010C22 peptide antibody titres in both haplotypes. Antigen\u2010stimulated Th1\/Th2 cytokine secretion by splenocytes and antibody isotypes indicated a Th2\u2010type immune response with IgG1 antibodies and a low titre of IgG2b. There was no serum bactericidal activity observed against the meningococcus.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2005.01671.x","type":"journal-article","created":{"date-parts":[[2005,9,27]],"date-time":"2005-09-27T13:10:14Z","timestamp":1127826614000},"page":"385-392","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Immunogenicity of a Conformationally Restricted Peptide Mimetic of Meningococcal Lipooligosaccharide"],"prefix":"10.1111","volume":"62","author":[{"given":"H.","family":"Tiwana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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