{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:13:16Z","timestamp":1760865196352},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to investigate the frequency of the \u22121082 polymorphism of the interleukin\u201010 (<jats:italic>IL\u201010<\/jats:italic>) gene and the soluble IL\u201010 levels in Hungarian primary Sj\u00f6gren's syndrome (SS) patients. Ninety\u2010nine SS patients and 135 healthy volunteers were examined. Samples were analysed by the PCR restriction fragment length polymorphism method, and IL\u201010 plasma levels were assesed by a commercial enzyme\u2010linked immunosorbent assay. IL\u201010 plasma levels were higher in the primary SS patients (36.4\u2003\u00b1\u200357.5\u2003pg\/ml, <jats:italic>n<\/jats:italic>\u2003=\u200399) compared with the healthy subjects (9.9\u2003\u00b1\u200320.3\u2003pg\/ml, <jats:italic>n<\/jats:italic>\u2003=\u2003135, <jats:italic>P<\/jats:italic>\u2003=\u200310<jats:sup>\u22126<\/jats:sup>). The elevated IL\u201010 phenotype of SS patients was not associated with increased G allele frequency as reported earlier, while in the control group, we found higher IL\u201010 levels among the subjects who were carriers of the GG genotype (17.7\u2003\u00b1\u200323.2\u2003pg\/ml) as compared with the other two genotype carriers (AA 8.98\u2003\u00b1\u200316.5 and GA 8.5\u2003\u00b1\u200321.1\u2003pg\/ml, <jats:italic>P<\/jats:italic>\u2003=\u20030.01). Our data do not support previous observations indicating an association between deregulated IL\u201010 secretion in SS and higher G allele frequency. However, the results clearly demonstrate that GG homozygosity is associated with elevated IL\u201010 levels in apparently healthy subjects, but this cannot account for the IL\u201010\u2010related specific disease features observed in SS. Thus, other genetic factors contribute to the clinical spectrum of this heterogeneous disease at least in the Hungarian population.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2005.01675.x","type":"journal-article","created":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T09:50:32Z","timestamp":1132307432000},"page":"474-480","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["IL\u201010 Promoter \u22121082 Polymorphism is Associated with Elevated IL\u201010 Levels in Control Subjects but Does not Explain Elevated Plasma IL\u201010 Observed in Sj\u00f6gren's Syndrome in a Hungarian Cohort"],"prefix":"10.1111","volume":"62","author":[{"given":"M.","family":"M\u00e1rka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Bessenyei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Zeher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Semsei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.2.295"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.149.7.2378"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.6.2081"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.5.1209"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.146.10.3444"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.4049\/jimmunol.147.8.2713","article-title":"Production of IL\u201010 by CD4+ T lymphocytes correlates with down\u2010regulation of Th1 cytokine synthesis in helminth infection","volume":"147","author":"Sher A","year":"1991","journal-title":"J Immunol"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.148.4.1143"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/7.8.1287"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60449-6"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00179416"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002510050174"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2370.1997.tb00001.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.5.1517"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)70489-X"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1997.tb02812.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780371114"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)06413-6"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0889-857X(21)00317-3","article-title":"Salivary and oral components of Sj\u00f6gren's syndrome","volume":"18","author":"Daniels T","year":"1992","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199909000-00007"},{"key":"e_1_2_5_21_2","first-page":"11","article-title":"Clinical and pathogenetic aspects of Sj\u00f6gren's syndrome","volume":"6","author":"Talal N","year":"1993","journal-title":"Semin Clin Immunol"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200103)44:3<638::AID-ANR112>3.0.CO;2-J"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1998.4520"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200101)44:1<176::AID-ANR23>3.0.CO;2-K"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000060495"},{"key":"e_1_2_5_27_2","first-page":"109","volume-title":"Clinical application of cytokines; 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