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Blood samples were collected from 78 paediatric patients suffering from CG associated with <jats:italic>Helicobacter pylori<\/jats:italic> infection (group Hp<jats:sup>+<\/jats:sup>) and from 41 with the disease not associated with such an infection (group Hp<jats:sup>\u2013<\/jats:sup>). Control group consisted of 77 children. The frequency of <jats:italic>mbl\u20102<\/jats:italic> gene mutations and serum protein concentrations did not differ significantly in both groups as compared with controls. An expression of <jats:italic>mbl\u20102<\/jats:italic> gene in gastric biopsies of CG patients was demonstrated. It was found to be stronger in <jats:italic>H. pylori\u2010<\/jats:italic>infected children. The results presented in this paper suggest that MBL deficit\/dysfunction probably does not contribute to an increased risk of CG (both associated and not associated with <jats:italic>H. pylori<\/jats:italic> infection) in children. However, MBL opsonic effect and\/or the lectin pathway of complement activation may be taken into account as possible host defence mechanisms in gastric patients.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2005.01719.x","type":"journal-article","created":{"date-parts":[[2006,2,14]],"date-time":"2006-02-14T11:10:27Z","timestamp":1139915427000},"page":"131-135","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Mannan\u2010Binding Lectin in Children with Chronic Gastritis"],"prefix":"10.1111","volume":"63","author":[{"given":"L.","family":"Ba\u0327k\u2010Romaniszyn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cedzy\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Szemraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"St. \u015awierzko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Zeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ka\u0142uz\u030ay\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"P\u0142aneta\u2010Ma\u0142ecka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,14]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(02)00321-5"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST0310753"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2001.1800108.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(01)00038-4"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1078\/0171-2985-00144"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93263-9"},{"key":"e_1_2_6_8_2","first-page":"660","article-title":"Distinct physicochemical characteristics of human mannose binding protein expressed by individuals of differing genotype","volume":"85","author":"Lipscombe RJ","year":"1995","journal-title":"Immunology"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3111021"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.155.6.3013"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.9.4553"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST0310748"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(96)80908-X"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)02563-5"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc1454"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08516-1"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/322791"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0703325"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/515690"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)05409-8"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007050050320"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1998.14.695"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.10.1316"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02453.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.1.95"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200003)43:3<515::AID-ANR6>3.0.CO;2-T"},{"key":"e_1_2_6_27_2","first-page":"728","article-title":"Low mannose binding lectin predicts poor diagnosis in patients with early rheumatoid arthritis. 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