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In the memory phase, VLA\u20101 deficiency did not influence the number of memory CD8<jats:sup>+<\/jats:sup> T cells or their distribution between lymphoid and nonlymphoid organs. Regarding a functional role of VLA\u20101, we found that intracerebral infection of both VLA\u20101<jats:sup>\u2013\/\u2013<\/jats:sup> and wild\u2010type (wt) mice resulted in lethal T\u2010cell\u2010mediated meningitis, and quantitative and qualitative analyses of the cellular exudate did not reveal any significant differences between the two strains. Expression of VLA\u20101 was also found to be redundant regarding the ability of effector T cells to eliminate virus from internal organs of i.v. infected mice. Using delayed\u2010type hypersensitivity (DTH) assays to evaluate subdermal CD8<jats:sup>+<\/jats:sup> T\u2010cell\u2010mediated inflammation, no significant influence of VLA\u20101 was found either in the primary response or in the memory phase. However, \u03b1\u2010VLA\u20104 antibody reduced the DTH\u2010like reaction in VLA\u20101<jats:sup>\u2013\/\u2013<\/jats:sup> mice to a higher degree than in wt mice, suggesting a synergistic effect of blocking both integrins. Taken together, the current findings indicate that the expression of VLA\u20101 is not pivotal for T\u2010cell\u2010mediated antiviral immunity to a systemic infection.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2006.01744.x","type":"journal-article","created":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T13:07:47Z","timestamp":1144242467000},"page":"290-298","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of Very Late Antigen\u20101 in T\u2010cell\u2010Mediated Immunity to Systemic Viral Infection"],"prefix":"10.1111","volume":"63","author":[{"given":"S. \u00d8.","family":"Kauffmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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