{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:50:47Z","timestamp":1791219047695,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,8,7]],"date-time":"2006-08-07T00:00:00Z","timestamp":1154908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inherent properties of dendritic cell (DC) subsets are important in the regulation of na\u00efve T\u2010cell differentiation (e.g. Th1 versus Th2 cells), whereas effector memory T cells are believed to produce a fixed cytokine repertoire independent of the type of antigen presenting cell. Here we show that two distinct human DC subsets, plasmacytoid DC (PDC) and myeloid CD11c+ DC, induced autologous mumps virus\u2010specific memory CD4<jats:sup>+<\/jats:sup> T cells to produce markedly different cytokine patterns upon antigen stimulation. PDC stimulated the T cells to produce <jats:italic>\u03b3<\/jats:italic>\u2010interferon (IFN\u2010<jats:italic>\u03b3<\/jats:italic>) and interleukin\u2010(IL)\u201010, whereas CD11c+ DC induced lower levels of IFN\u2010<jats:italic>\u03b3<\/jats:italic>, virtually no IL\u201010, but significant levels of IL\u20105. Analysis of intracellular cytokine production showed simultaneous production of IL\u201010 and IFN\u2010<jats:italic>\u03b3<\/jats:italic> in mumps\u2010specific T cells activated by PDC, a cytokine pattern similar to that described for Th1\u2010like regulatory cells. Introduction of CpG oligodeoxynucleotides in PDC\/T\u2010cell co\u2010cultures had synergistic effect on virus\u2010dependent IFN\u2010<jats:italic>\u03b3<\/jats:italic> production, whereas the other cytokines remained unchanged. Together, our results show that the type of DC involved in reactivation of previously primed T cells may have significant impact on the resulting cytokine response and suggest that targeting of viral antigens and adjuvant to specific DC subsets should be considered in the design of therapeutic antiviral vaccines.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2006.01792.x","type":"journal-article","created":{"date-parts":[[2006,8,7]],"date-time":"2006-08-07T15:07:18Z","timestamp":1154963238000},"page":"404-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Plasmacytoid Dendritic Cells Induce a Distinct Cytokine Pattern in Virus\u2010Specific CD4<sup>+<\/sup> Memory T Cells that is Modulated by CpG Oligodeoxynucleotides"],"prefix":"10.1111","volume":"64","author":[{"given":"L.","family":"Farkas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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