{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:21:22Z","timestamp":1773289282361,"version":"3.50.1"},"reference-count":70,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,8,9]],"date-time":"2006-08-09T00:00:00Z","timestamp":1155081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p> <jats:italic>Mycobacterium tuberculosis<\/jats:italic>, the causative agent of tuberculosis (TB), is one of the main killers among infectious pathogens in the world and represents an important factor that sustain poverty in developing countries. Failure of the BCG vaccine to protect in endemic regions, and increasing problems with multi\u2010drug\u2010resistant TB calls for development of better vaccines to prevent reactivation of tuberculosis. It has been estimated that an effective post\u2010exposure vaccine will prevent 30\u201340% of the TB cases. New vaccines should also prevent development of TB in HIV\u2010infected individuals. Recent characterization of <jats:italic>M. tuberculosis<\/jats:italic> H37Rv by proteomic methods has revealed a large number of novel secreted proteins that should be investigated in mouse models for latent and slowly progressive TB. There is an important balance between control of infection and tissue destruction in TB, and <jats:italic>M. tuberculosis<\/jats:italic> has developed strategies to prevent immune\u2010mediated sterilization. Central to this strategy is inhibition of apoptosis of macrophages. Development of novel vaccines should therefore take into consideration the effects on central markers to obtain a better picture of regulation of immunity, including FasL and Bcl\u20102 which are essential in regulation of apoptosis.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2006.01815.x","type":"journal-article","created":{"date-parts":[[2006,8,9]],"date-time":"2006-08-09T13:59:12Z","timestamp":1155131952000},"page":"243-250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Vaccine Approaches to Prevent Tuberculosis"],"prefix":"10.1111","volume":"64","author":[{"given":"H. G.","family":"Wiker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"M\u00e5len","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M. D.","family":"Riise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,9]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.7.677"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.03.006"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.qco.0000168380.08895.9a"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1009.030921"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.17.2086"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510330076038"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92348-9"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67145-0"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.03.012"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.9.5299"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.250480397"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.2.934"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.03.009"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1128"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.03.010"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(02)00289-X"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.03.013"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.12.7618"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.10.6148-6150.2004"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.10.6332"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.04.003"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.3.514"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsim.2004.01.004"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.03.008"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.1999.00596.x"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655498750002321"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1086\/314640"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1159\/000234153"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1159\/000234154"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.56.4.648-661.1992"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/31159"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01549.x"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2683(20000301)21:5<935::AID-ELPS935>3.0.CO;2-P"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(01)00436-X"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.65.11.4515-4524.1997"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.4.2323-2327.2000"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-137-4-875"},{"key":"e_1_2_11_39_2","volume-title":"Late Breaker: Revealing the Secreted Proteome of Mycobacterium tuberculosis H37Rv. 19\u20134\u20102006","author":"Wiker HG"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.1997.d01-150.x"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0923-2508(91)90097-T"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.65.5.1856-1862.1997"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.6.3146-3154.2003"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-8244(03)00172-X"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.3.514"},{"key":"e_1_2_11_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1995.tb03624.x"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.1996.d01-78.x"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00724.x"},{"key":"e_1_2_11_49_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1128\/IAI.66.1.289-296.1998","article-title":"MPB70 and MPB83 as indicators of protein localization in mycobacterial cells","volume":"66","author":"Harboe M","year":"1998","journal-title":"Infect Immun"},{"key":"e_1_2_11_50_2","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1128\/iai.63.2.672-675.1995","article-title":"Relationship of Secretion Pattern and MPB70 Homology with Osteoblast\u2010Specific Factor\u20102 to Osteitis Following Mycobacterium bovis BCG Vaccination","volume":"63","author":"Ulstrup JC","year":"1995","journal-title":"Infect Immun"},{"key":"e_1_2_11_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04041.x"},{"key":"e_1_2_11_52_2","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1128\/IAI.66.7.3190-3197.1998","article-title":"Identification of new cytotoxic T\u2010cell epitopes on the 38\u2010kilodalton lipoglycoprotein of Mycobacterium tuberculosis by using lipopeptides","volume":"66","author":"Da Fonseca DP","year":"1998","journal-title":"Infect Immun"},{"key":"e_1_2_11_53_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5428.732"},{"key":"e_1_2_11_54_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23867"},{"key":"e_1_2_11_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80694-7"},{"key":"e_1_2_11_56_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00755.x"},{"key":"e_1_2_11_57_2","doi-asserted-by":"publisher","DOI":"10.1086\/314667"},{"key":"e_1_2_11_58_2","first-page":"389","volume-title":"Tuberculosis, Pathogenesis, Protection and Control","author":"Chan J","year":"1994"},{"key":"e_1_2_11_59_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.4.1499"},{"key":"e_1_2_11_60_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2002.01140.x"},{"key":"e_1_2_11_61_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.1.430"},{"key":"e_1_2_11_62_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2001.01020.x"},{"key":"e_1_2_11_63_2","first-page":"507","article-title":"Increased expression of Fas ligand on Mycobacterium tuberculosis infected macrophages: a potential novel mechanism of immune evasion by Mycobacterium tuberculosis","volume":"23","author":"Mustafa T","year":"1999","journal-title":"Inflammation"},{"key":"e_1_2_11_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2004.02080.x"},{"key":"e_1_2_11_65_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5284.67"},{"key":"e_1_2_11_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81005-3"},{"key":"e_1_2_11_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199806)28:06<1798::AID-IMMU1798>3.0.CO;2-E"},{"key":"e_1_2_11_68_2","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.4049\/jimmunol.162.3.1423","article-title":"Induction of specific T cell tolerance by Fas ligand\u2010expressing antigen\u2010presenting cells","volume":"162","author":"Zhang HG","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_11_69_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7533326"},{"key":"e_1_2_11_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03493-0"},{"key":"e_1_2_11_71_2","first-page":"1","article-title":"Tubercle bacilli in latent TB lesions and in lung tissue without tuberculous lesions","volume":"4","author":"Opie EL","year":"1927","journal-title":"Arch Path Lab Med"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3083.2006.01815.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3083.2006.01815.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T18:38:54Z","timestamp":1696876734000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3083.2006.01815.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,9]]},"references-count":70,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1365-3083.2006.01815.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3083.2006.01815.x","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,9]]},"assertion":[{"value":"2006-08-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}