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In recent years, the NOD mouse has become an accepted model of SjS, exhibiting a spontaneously developing disease that strongly mimics the human condition. Two genetic regions, one on chromosome 1 (designated <jats:italic>Aec2<\/jats:italic>) and the second on chromosome 3 (designated <jats:italic>Aec1<\/jats:italic>) of NOD mice, have been shown to be necessary and sufficient to recapitulate SjS\u2010like disease in non\u2010susceptible C57BL\/6 mice. Here we describe a newly derived strain, C57BL\/6.NOD\u2010<jats:italic>Aec1R1Aec2<\/jats:italic>, in which a recombination in <jats:italic>Aec1<\/jats:italic> has resulted in reducing this genetic region to less than 20\u2003cM from 48.5\u2003cM. Profiling of this recombinant inbred strain has revealed that male mice maintain a full SjS\u2010like disease, whereas female mice exhibit stomatitis sicca in the absence of detectable keratoconjunctivitis sicca. These data suggest SjS\u2010like disease in the NOD mouse shows gender\u2010specific regulation determined by autosomal genes.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2006.01828.x","type":"journal-article","created":{"date-parts":[[2006,8,9]],"date-time":"2006-08-09T13:59:12Z","timestamp":1155131952000},"page":"295-307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Sj\u00f6gren's Syndrome\u2010Like Disease of C57BL\/6.NOD\u2010<i>Aec1 Aec2<\/i> Mice: Gender Differences in Keratoconjunctivitis Sicca Defined by a Cross\u2010Over in the Chromosome 3 <i>Aec1<\/i> Locus"],"prefix":"10.1111","volume":"64","author":[{"given":"C.","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Singson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010Y.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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