{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:20:01Z","timestamp":1774437601267,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,9,14]],"date-time":"2006-09-14T00:00:00Z","timestamp":1158192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytokines play a crucial role in the pathogenesis of autoimmune thyroid disease. The aim of this study was to investigate the relationship of the single base change polymorphic variants identified in the first intron of interferon\u2010gamma (IFN\u2010<jats:italic>\u03b3<\/jats:italic>) (+874 T\/A) with susceptibility to thyroid dysfunctions. A total of 340 subjects were included in the study comprising of 190 patients (104 patients with Hashimoto's thyroiditis, 26 with non\u2010Hashimoto's hypothyroidism and 60 Graves\u2019 disease) and 150 controls. Genotyping was done by amplification refractory mutation system\u2010polymerase chain reaction using a set of sequence\u2010specific primers. Statistical analysis revealed a significant association between high IFN\u2010<jats:italic>\u03b3<\/jats:italic>\u2010producing genotype TT and Hashimoto's thyroiditis compared to controls (<jats:italic>P<\/jats:italic> value\u2003&lt;\u20030.001). On the other hand, the frequency of genotype TT was decreased in patients with Graves\u2019 hyperthyroidism with a significant increase in low IFN\u2010<jats:italic>\u03b3<\/jats:italic>\u2010producing genotype AA among this group (<jats:italic>P<\/jats:italic>\u2003=\u20030.03). To conclude the results of the study suggest a differential association of high\u2010 and low\u2010producing alleles of IFN\u2010<jats:italic>\u03b3<\/jats:italic> gene with Hashimoto's thyroiditis and Graves\u2019 disease. The high IFN\u2010<jats:italic>\u03b3<\/jats:italic>\u2010producing allele T was observed to be associated with Hashimoto's thyroiditis in the present study where as in Graves\u2019 hyperthyroidism the association was observed to be stronger with the low producing allele A.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2006.01834.x","type":"journal-article","created":{"date-parts":[[2006,9,14]],"date-time":"2006-09-14T08:31:54Z","timestamp":1158222714000},"page":"438-443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A Differential Association of Interferon\u2010<i>\u03b3<\/i> High\u2010Producing Allele T and Low\u2010Producing Allele A (+874 A\/T) with Hashimoto's Thyroiditis and Graves\u2019 Disease"],"prefix":"10.1111","volume":"64","author":[{"given":"P. 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