{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:19:50Z","timestamp":1791227990739,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T00:00:00Z","timestamp":1160956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interleukin\u201015 (IL\u201015) is a novel proinflammatory cytokine, involved in the pathogenesis of inflammatory\/autoimmune disease. The objective of our study was to measure serum and cerebrospinal fluid (CSF) IL\u201015 levels in patients with Beh\u00e7et's disease (BD). CSF\/serum IL\u201015 ratio was introduced to assess the origin of elevated IL\u201015 levels. We measured serum and CSF\u2010IL\u201015 levels in 40 patients with BD (20 patients in active stage). Inflammatory and non\u2010inflammatory neurological disease patients acted as controls. Active BD patients have significantly higher serum IL\u201015 levels (median 10.4\u2003pg\/ml; range 5.3\u201317.4) compared with BD in remission (6.05\u2003pg\/ml; 4\u201310.4) and healthy controls (4.65\u2003pg\/ml; 3.9\u20136.2). Similar serum IL\u201015 levels were found in active neuro\u2010BD and inflammatory neurological disease (9.5\u2003pg\/ml; 5\u201313). Elevated levels of IL\u201015 were observed in CSF samples from neuro\u2010BD patients (11\u2003pg\/ml; 8.5\u201315) and inflammatory neurological disease patients (10\u2003pg\/ml; 6.5\u201314) compared with patients with non\u2010inflammatory neurological disease (4\u2003pg\/ml; 4\u20135.5; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Vascular cerebral BD lesions were associated with high CSF\/serum IL\u201015 ratio. Our findings suggest that IL\u201015 is involved in BD inflammatory process, particularly in vasculitis foci, as an elevated CSF\/serum IL\u201015 ratio characterizes vascular cerebral lesions.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2006.01844.x","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T06:12:47Z","timestamp":1161151967000},"page":"655-660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Levels of IL\u201015 in Serum and Cerebrospinal Fluid of Patients with Beh\u00e7et's 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