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Some studies have focused on fungus\u2013host interaction, showing a predominantly cell\u2010mediated immune response, with the activation of macrophages involved in fungus phagocytosis. Immunization with live conidia produced a high influx of CD4 T cells into the draining lymph node. The sensitized T cells proliferate <jats:italic>in vitro<\/jats:italic> when restimulated with specific antigen and preferentially produce IFN\u2010 <jats:italic>\u03b3<\/jats:italic>. To better characterize the role played by T cells on the chromoblastomycosis infection we used mice deficient for CD4 and CD8. Data determined by CFU counts associated with decreased DTH and IFN\u2010<jats:italic>\u03b3<\/jats:italic> production of infected mice clearly demonstrated that, during experimental <jats:italic>F. pedrosoi<\/jats:italic> infection, absence of CD4<jats:sup>+<\/jats:sup> cells induces a more severe disease.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2006.01846.x","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T06:12:47Z","timestamp":1161151967000},"page":"595-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Absence of CD4<sup>+<\/sup> T Cells Impairs Host Defence of Mice Infected with <i>Fonsecaea pedrosoi<\/i>"],"prefix":"10.1111","volume":"64","author":[{"given":"M. da Gloria","family":"Teixeira de Sousa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. E. 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