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Twenty five female BALB\/c mice (age: 8 weeks) were randomly divided into 5 groups: Ovabumin (OVA); OVA peptide amino acid residues No. 323\u2013339 (Pep); TDI; alum and physiological saline. Mice were intraperitoneally injected with 25 \u03bcg OVA or pep absorbed on 300 \u03bcg alum, 300 \u03bcg alum or saline on days 0, 7 and 14. For the TDI group, mice were sensitized subcutaneously with 20 \u03bcl neat TDI on day 0; 20 \u03bcl of TDI in olive oil (1:10) on days 7 and 14; on days 21\u201323. Then each group was challenged intranasally with 20 \u03bcl of 1% OVA, 1% Pep, 1% TDI, 10% alum and saline respectively. On day 28, mice were killed under pentothal anesthesia. The results demonstrated that neutrophil\u2010dominant inflammation with a few eosinophil infiltration occurred in the peri\u2010bronchial and peri\u2010vascular regions of the lungs. This was accompanied by hyperplasia\/hypertrophy of cells lining the airways and mucus production as shown by HE staining. Positive immunohistochemical MBP staining in parenchyma was also shown. Th2 cytokine IL\u20104 and IgE production were significant increased 5 days after last challenge while IFN\u2010\u03b3 level was below the detection limit. Conclusion: the clear elevation of IL\u20104 and IgE could allow to conclude a possible Th2\u2010like dominated allergic response in TDI\u2010exposed BALB\/c mouse model.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2006.01882.x","type":"journal-article","created":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T22:39:04Z","timestamp":1166135944000},"page":"118-125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Airway Inflammation and Bronchial Remodelling in Toluene Diisocyanate\u2010exposed BALB\/<i>c<\/i> Mouse Model"],"prefix":"10.1111","volume":"65","author":[{"given":"L.\u2010Z.","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Elsayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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