{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:23Z","timestamp":1761058643413},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunoglobulin (Ig) E may provide immunity against <jats:italic>Borrelia burgdorferi<\/jats:italic> infection (Lyme disease) in children which lasts throughout adulthood. We investigated the presence and persistence of IgE anti\u2010<jats:italic>B. burgdorferi<\/jats:italic> antibodies (Abs) in paediatric patients infected with Lyme disease over time. Serum immunoglobulin levels, presence of IgG and IgE anti\u2010<jats:italic>B. burgdorferi<\/jats:italic> components, and distributions of blood T, B and natural killer lymphocyte subsets were studied in <jats:italic>B. burgdorferi<\/jats:italic>\u2010infected and \u2010uninfected children (nephelometry, UniCAP Total IgE Fluoroenzymeimmunoassay, Western blot, flow cytometry). Total serum IgM, IgG, IgE and IgA levels, and distributions of blood lymphocytes (CD4<jats:sup>+<\/jats:sup>, CD8<jats:sup>+<\/jats:sup>, CD19<jats:sup>+<\/jats:sup>) of both groups, excluding CD8<jats:sup>+<\/jats:sup>CD60<jats:sup>+<\/jats:sup> T cells, were within normal ranges. However, infected, but not uninfected children made IgG anti\u2010<jats:italic>B. burgdorferi<\/jats:italic> proteins p18, p31, p34, p41, p45, but not IgG anti\u2010p60, and IgE anti\u2010<jats:italic>B. burgdorferi<\/jats:italic> proteins p31, p34, p41, p45, p60, but not IgE anti\u2010p18. These proteins were also detected in an infected child 1\u2003year post\u2010infection. Interestingly, CD8<jats:sup>+<\/jats:sup>CD60<jats:sup>+<\/jats:sup> T\u2010cell numbers were significantly increased (fourfold) in infected, compared with uninfected, patients (<jats:italic>P<\/jats:italic>\u2003=\u20030.001). These results demonstrate that specific IgE anti\u2010<jats:italic>B. burgdorferi<\/jats:italic> Abs are generated and persist in children with Lyme disease and that CD8<jats:sup>+<\/jats:sup>CD60<jats:sup>+<\/jats:sup> T cells may play an important role in these responses.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2007.01904.x","type":"journal-article","created":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T16:50:19Z","timestamp":1173459019000},"page":"376-382","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["IgE Anti\u2010<i>Borrelia burgdorferi<\/i> Components (p18, p31, p34, p41, p45, p60) and Increased Blood CD8<sup>+<\/sup>CD60<sup>+<\/sup> T Cells in Children with Lyme Disease"],"prefix":"10.1111","volume":"65","author":[{"given":"M. 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